Results 111 to 120 of about 172,712 (346)

Innovative Drugs Approved in China After Registration Classification Reform: Current Status, Disparities, and Challenges

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Since 2016, the China National Medical Products Administration (NMPA) has reformed its drug registration classification rules and defines the innovative drugs as new drugs that have not been marketed domestically and overseas. This study sought to systematically evaluate the characteristics of the innovative drugs approved in China. The cross‐sectional
Xingyue Zhu, Die Xiao
wiley   +1 more source

The Pattern of Sensitisation to Inhalant Allergens in Omani Patients with Asthma, Allergic Rhinitis and Rhinoconjunctivitis

open access: yesSultan Qaboos University Medical Journal, 2008
Objective: Identification of relevant allergens that are prevalent in each environment which may have diagnostic and therapeutic implications in allergic diseases.
Salem H Al-Tamemi   +5 more
doaj  

RORγt‐APCs: The New Masters of Oral Tolerance

open access: yesBarrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

The Use of Peptide Markers of Carp and Herring Allergens as an Example of Detection of Sequenced and Non-Sequenced Proteins

open access: yesFood Technology and Biotechnology, 2016
The objective of this study is to identify fish protein markers for detecting multiple species based on a comparative proteomic approach that relies on fragments with identical sequences.
Justyna Bucholska, Piotr Minkiewicz
doaj   +1 more source

CONVEGNO LA RICERCA PER L’AGRICOLTURA BIOLOGICA E BIODINAMICA: UNA VISIONE DI INSIEME [PDF]

open access: yes, 2016
This Conference was organized by the Italian Ministry of Agriculture and was aimed to an overview of the Research in Organic Farming in Italy.
Roberto, Lo Scalzo
core  

A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years [PDF]

open access: yes, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher ...
AlKandari, F   +7 more
core   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

open access: yesBarrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia   +4 more
wiley   +1 more source

Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma [PDF]

open access: yes, 2017
The pathophysiology of allergic asthma is driven by T-helper 2 (Th2) immune responses following aeroallergen inhalation. The mechanisms that initiate, potentiate and regulate airways allergy are incompletely characterized.
Crompton, Tessa   +4 more
core   +2 more sources

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl   +14 more
wiley   +1 more source

Cosmetic Contact Allergens

open access: yesCosmetics, 2016
This article presents trends in the frequency of cosmetics as causal factors of allergic contact dermatitis during a 26-year period in 14,911 patients patch-tested between 1990 and 2014, and discusses the cosmetic allergens identified during the last six
An Goossens
doaj   +1 more source

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