Results 1 to 10 of about 221,286 (209)

Does unified allergic airway disease impact on lung function and type 2 biomarkers? [PDF]

Allergy, Asthma & Clinical Immunology, 2019
The concept of the unified allergic airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experience more asthma-related primary and secondary ...
Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +2 more
doaj   +4 more sources

The levels and impacting factors of serum amyloid A in the acute exacerbation of allergic asthma [PDF]

Yixue xinzhi zazhi, 2022
Objective To analyze the expression levels of serum amyloid A (SAA) in patients with allergic and non-allergic asthma, and explore the correlation between SAA and acute exacerbation severity and identify biomarkers of allergic asthma.Methods Asthmatic ...
Yan-Wen CUI, Li-Hui WANG, Chun-Xian DU, Ya-Dong GAO   +3 more
doaj   +1 more source

A systems immunology approach to investigate cytokine responses to viruses and bacteria and their association with disease

Scientific Reports, 2022
Patterns of human immune responses to viruses and bacteria and how this impacts risk of infections or onset/exacerbation of chronic respiratory diseases are poorly understood.
Lijing Lin, John A. Curtin, Eteri Regis, Aurica Hirsman, Rebecca Howard, Mauro Tutino, Michael R. Edwards, Mattia Prosperi, Angela Simpson, Magnus Rattray, Adnan Custovic, Sebastian L. Johnston   +11 more
doaj   +1 more source

Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium

Frontiers in Genetics, 2020
BackgroundAsthma is a chronic airway disease driven by complex genetic–environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood.MethodsWe piloted genome-wide profiling of the ...
Peter McErlean, Peter McErlean, Audrey Kelly, Audrey Kelly, Jaideep Dhariwal, Jaideep Dhariwal, Max Kirtland, Max Kirtland, Julie Watson, Julie Watson, Ismael Ranz, Ismael Ranz, Janet Smith, Alka Saxena, David J. Cousins, David J. Cousins, Antoon Van Oosterhout, Roberto Solari, Roberto Solari, Michael R. Edwards, Michael R. Edwards, Sebastian L. Johnston, Sebastian L. Johnston, Paul Lavender, Paul Lavender   +24 more
doaj   +1 more source

Age at asthma diagnosis and onset of symptoms among adults with allergic and non-allergic asthma

European Clinical Respiratory Journal, 2023
Background Childhood-onset allergic asthma is the best-known phenotype of asthma. Adult-onset asthma, also an important entity, is instead often shown to be more non-allergic.
Johanna Pakkasela, Petri Salmela, Pekka Juntunen, Jussi Karjalainen, Lauri Lehtimäki   +4 more
doaj   +1 more source

The effect of residential urban greenness on allergic respiratory diseases in youth: A narrative review [PDF]

, 2020
Background: Environmental exposures across the life course may be a contributor to the increased worldwide prevalence of respiratory and allergic diseases occurring in the last decades.
Asta F, Cilluffo G, De Sario M, Ferrante G, La Grutta S, Michelozzi P   +5 more
core   +1 more source

Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Allergy, Asthma & Clinical Immunology, 2021
Background Investigating the endotypes of the different asthma phenotypes would help disease monitoring, prognosis determination, and improving asthma management standardization.
Yi Jiang, Ruoli An, Li Cheng, Qianru Yue, Hanwei Zhang, Yali Zhang, Xiaomei Kong, Hongxia Ma, Fang Chen, Yufeng Guo   +9 more
doaj   +1 more source

γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation [PDF]

, 2015
T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for ...
Li, Changchong, Sheng, Anqun, Weng, Cuiye, Zhang, Weixi, Zhang, Xueya, Zhao, Wei, Zhu, Tingting   +6 more
core   +8 more sources

Incidence and timing of offspring asthma, wheeze, allergic rhinitis, atopic dermatitis, and food allergy and association with maternal history of asthma and allergic rhinitis

World Allergy Organization Journal, 2021
Background: Studying the developmental precursors of allergy may help explain the mechanisms (or etiology) of allergic disease. We studied childhood respiratory and allergic diseases in a pre-birth cohort from the United States.
Carina Venter, Michaela P. Palumbo, Katherine A. Sauder, Deborah H. Glueck, Andrew H. Liu, Ivana V. Yang, Miriam Ben-Abdallah, David M. Fleischer, Dana Dabelea   +8 more
doaj   +1 more source

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
A Abe, A Duguet, A Hoshino, A Vazquez-Tello, A Vazquez-Tello, AG Besnard, AG Besnard, AI Caceres, AJ Coyle, AR Brasier, AR Sousa, AS Saffar, AT Hastie, B Korkmaz, Benjamin T. Suratt, BJ Canning, C Sutton, C Taube, D Stejskal, Daniel J. Weiss, DB Corry, DC Newcomb, DC Newcomb, DC Newcomb, DH Broide, E Goleva, F Kirstein, GJ Zijlstra, H Fujie, H Koga, H Wakashin, Hong Wei Chu, I Tillie-Leblond, J Agbetile, J Chang, J Seok, J Sunyer, J Zhao, JB Cowland, Jennifer L. Ather, JH Bates, JH Lee, JL Ather, JL Ather, John F. Alcorn, JR Karlsen, JV Fahy, K Raemdonck, K Yang, L McKinley, LA Cooney, Laura Hoyt, Lennart K. A. Lundblad, LJ Akinbami, LK Lundblad, LK Lundblad, LK Lundblad, LL Reber, M Bevelander, M Kawaguchi, M Kudo, M Leppkes, M Suzukawa, MA Willart, Matthew E. Poynter, ME Poynter, ME Poynter, ME Poynter, MH Brutsche, MH Shaw, MW Kinyanjui, N Schmitz, PA Wark, PL Delamater, PS Foster, PW Hellings, Q Wang, R He, RA Martin, Rebecca A. Martin, Rebecca Daggett, RH Wilson, S Ano, S Dragon, S Ferretti, S Haak, S Lajoie, S Molet, S Schnyder-Candrian, S Suzuki, S Wenzel, SJ Ballantyne, SM Hu, SP Chapoval, SR Hodgkins, T Li, VJ Johnson, W Al-Ramli, WP Arend, WW Lee, X Yao, XY Chi, Y Chung, Y Liu, Y Takenoue, Y Zhao, YH Wang   +106 more
core   +8 more sources