Results 41 to 50 of about 217,585 (300)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Peanut allergy:effect of environmental peanut exposure in children with filaggrin loss-of-function mutations [PDF]

, 2014
BackgroundFilaggrin (FLG) loss-of-function mutations lead to an impaired skin barrier associated with peanut allergy. Household peanut consumption is associated with peanut allergy, and peanut allergen in household dust correlates with household peanut ...
Makinson, Kerry, Hankinson, Jenny, Brown, Sara, Adnan Custovic, Nicolaos Nicolaou, McLean, W.H. Irwin, Simpson, Angela, Stephens, Alick C, Nicolaou, Nicolaos, Abdel Douiri, Simpson, Angela; id_orcid, Belgrave, Danielle C M, Kerry Makinson, Helen A. Brough, McLean, W. H. Irwin, Stephens, Alick C., Sara Brown, Brough, Helen A., Alick C. Stephens, Penagos, Martin, Turcanu, Victor, Danielle C.M. Belgrave, Lack, Gideon, Victor Turcanu, Custovic, Adnan, Belgrave, Danielle C. M., Martin Penagos, Jenny Hankinson, Gideon Lack, W.H. Irwin McLean, Brough, Helen A.; id_orcid, Belgrave, Danielle C.M., Douiri, Abdel; id_orcid, McLean, W H Irwin, Douiri, Abdel, Brough, Helen A, Angela Simpson   +36 more
core   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Is There a Need for Repetition of Skin Test in Childhood Allergic Diseases? Repetition of Skin Test and Allergic Diseases

Allergology International, 2014
Background: Skin prick tests are widely used to determine sensitivity in allergic diseases. There is limited information about the natural history of skin sensitization tests and factors that affect them.
Mahmut Dogru, Ilknur Bostanci, Serap Ozmen, Tayfur Ginis, Handan Duman   +4 more
doaj   +1 more source

Allergic sensitization: host‐immune factors [PDF]

Clinical and Translational Allergy, 2014
AbstractAllergic sensitization is the outcome of a complex interplay between the allergen and the host in a given environmental context. The first barrier encountered by an allergen on its way to sensitization is the mucosal epithelial layer. Allergic inflammatory diseases are accompanied by increased permeability of the epithelium, which is more ...
van Ree, Ronald, Hummelshøj, Lone, Plantinga, Maud, Poulsen, Lars K., Swindle, Emily   +4 more
openaire   +3 more sources

Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity. [PDF]

, 2010
BACKGROUND: The low prevalence of allergic disease in the rural tropics has been attributed to the protective effects of chronic helminth infections. There is concern that treatment-based control programmes for these parasites may lead to an increase in ...
Oviedo, G, M. Vaca, I. Quinzo, L. C. Rodrigues, Rodriguez, A, Rodrigues, LC, Moncayo, A-L, M. E. Chico, Chico, ME, G. Oviedo, Lovato, R, Endara, P, P. J. Cooper, R. Lovato, M. L. Barreto, Quinzo, I, A.-L. Moncayo, P. Endara, Vaca, M, Erazo, S, A. Rodriguez, Barreto, ML, S. Erazo, Moncayo, AL, Cooper, PJ   +24 more
core   +1 more source

Exposure amount and timing of solar irradiation during pregnancy and the risk of sensitization in children

Allergology International, 2018
Background: Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children.
Hyun Yong Koh, Eunhae Cho, So-Yeon Lee, Woo Kyung Kim, Yong Mean Park, Jihyun Kim, Kangmo Ahn, Seung Won Lee, Mi Ae Kim, Myung-Il Hahm, Yoomi Chae, Kee-Jae Lee, Ho-Jang Kwon, Man Yong Han   +13 more
doaj   +1 more source

Inflammatory response and IgE sensitization at early age

, 2013
Microbial exposure may induce low-grade inflammation at an early age and decrease the risk of allergic diseases, as suggested by the hygiene hypothesis.
Roduit, Caroline; https://orcid.org/, Kirsi Mustonen, Leea Keski‐Nisula, Hyvarinen, Anne, Caroline Roduit, Orivuori, Laura, Anne Hyvärinen, Bianca Schaub, Roger Lauener, Erika von Mutius, Jean‐Charles Dalphin, von Mutius, Erika, Charlotte Braun‐Fahrländer, Vaarala, Outi, Laura Orivuori, Josef Riedler, Braun-Fahrlaender, Charlotte, Schaub, Bianca, Renseigné, Non, Mustonen, Kirsi, Lauener, Roger, Pasture Study Group,, Dalphin, Jean-Charles, Pekkanen, Juha, Juha Pekkanen, Riedler, Josef, Roduit, Caroline, Genuneit, Jon, Juliane Weber, Outi Vaarala, Keski-Nisula, Leea, Petra Ina Pfefferle, Braun-Fahrländer, Charlotte, Weber, Juliane, Pfefferle, Petra Ina, Jon Genuneit   +35 more
core   +1 more source

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy [PDF]

, 2015
BACKGROUND: History and severity of atopic dermatitis (AD) are risk factors for peanut allergy. Recent evidence suggests that children can become sensitized to food allergens through an impaired skin barrier.
Sicherer, Scott, Brough, Helen A., Makinson, Kerry, Burks, Wesley, Turcanu, Victor, Jones, Stacie M., Liu, Andrew H., Lack, Gideon, Brown, Sara J., Sampson, Hugh, Wood, Robert A., Douiri, Abdel; id_orcid, Stablein, Donald, Dawson, Peter, Douiri, Abdel, McLean, W. H. Irwin, Stephens, Alick C., Irwin McLean, W.H.   +17 more
core   +1 more source

Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells.

PLoS ONE, 2011
Chlamydia pneumoniae (CP) is associated with induction and exacerbation of asthma. CP infection can induce allergic airway sensitization in mice in a dose- and time-dependent manner.
Timothy R Crother, Nicolas W J Schröder, Justin Karlin, Shuang Chen, Kenichi Shimada, Anatoly Slepenkin, Randa Alsabeh, Ellena Peterson, Moshe Arditi   +8 more
doaj   +1 more source