Results 61 to 70 of about 217,585 (300)

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. [PDF]

, 2014
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Newton, GK, Jenkins, K, Robinson, C, Garrod, DR, Richardson, JP, Key, RE, Perrior, TR, Major, MR, Firth-Clark, S, Chen, J, Francis-Newton, NJ, Lloyd, SM, Stewart, MR, Zhang, J, Lai, P   +14 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Frequency of new sensitization in patients experiencing symptom recurrence during allergen immunotherapy

Egyptian Journal of Chest Disease and Tuberculosis
Introduction Allergen immunotherapy should be personalized according to the allergen sensitization pattern and the clinical impact of allergens. Sensitization, or the existence of antibodies for specific allergens, is a necessary step for developing an ...
Eman A. Saied, Mohammed Shehta, Ahmad Y. Badawy, Heba W. Abdelwahab   +3 more
doaj   +1 more source

Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two. [PDF]

, 2014
BACKGROUND: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. METHODS: Cross-sectional studies of stratified random samples of 8-12-year-old children (n = 10 652) (16 centres in ...
Forastiere, Francesco, Forastiere, F, Jaensch, A., Nagel, G, Jaensch Andrea, David P. Strachan, Gudrun Weinmayr (669480), Forastiere Francesco, Büchele Gisela, Strachan, D.P., Weinmayr, Gudrun, Gabriele Nagel (276147), Büchele, Gisela, Nagel, Gabriele, Gabriele Nagel, Jaensch, Andrea, Andrea Jaensch, Weinmayr Gudrun, Gisela Büchele, David P. Strachan (110302), Strachan, David P., Nagel Gabriele, Weinmayr, G, Strachan, DP, Andrea Jaensch (567644), Gudrun Weinmayr, Gisela Büchele (567645), David P Strachan, Weinmayr, G., Francesco Forastiere (669481), Strachan David P., ISAAC Phase Two Study Group, Büchele, G., Forastiere, F., Strachan, David P, Büchele, G, Jaensch, A, Francesco Forastiere, Nagel, G., ?, ?   +39 more
core   +3 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Determinants of sensitization to allergen in infants and young children [PDF]

Korean Journal of Pediatrics, 2014
Atopic sensitization is a complex phenomenon that changes dynamically with age throughout childhood; its prevalence increases with age in young children.
Hyeong Yun Kim, Youn Ho Shin, Man Yong Han   +2 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Allergic Sensitization and the Environment: Latest Update [PDF]

Current Allergy and Asthma Reports, 2014
The prevalence of asthma and other allergic diseases is still increasing both in developed and developing countries. Allergic sensitization against common inhalant allergens is common and, although not sufficient, a necessary step in the development of allergic diseases.
Young, Yoo, Matthew S, Perzanowski
openaire   +2 more sources

Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers [PDF]

, 2009
This is one of series of review articles on formaldehyde and formaldehyde-releasers (others: formaldehyde in cosmetics, in clothes and in metalworking fluids and miscellaneous).
Mari-Ann Flyvholm, Menne, T., Gerda Lensen, Pieter-Jan Coenraads, Menne, Torkil, Torkil Menné, Lensen, Gerda, de Groot, A.C., Coenraads, P.J., Lensen, G., Coenraads, Pieter-Jan, Flyvholm, Mari-ann, Anton C de Groot, de Groot, Anton C., de Groot, Anton C, Flyvholm, M.A.   +15 more
core   +2 more sources