Results 91 to 100 of about 32,744 (263)

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma‐1 and GABA_Areceptors [PDF]

, 2009
Seo‐Yeon Yoon, Dae‐Hyun Roh, Hyoung‐Sig Seo, Suk‐Yun Kang, Ho Jae Han, Alvin J. Beitz, Jang‐Hern Lee   +6 more
openalex   +1 more source

Exploratory Pain Profiling With Quantitative Sensory Testing (QST) in Episodic and Chronic Migraine

European Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Migraine pain profiling studies vary by sensory modalities, methods, anatomical sites and characteristics. This exploratory study aimed to identify pain profiling parameters using quantitative sensory testing (QST) for episodic migraine (EM) and chronic migraine (CM) and investigate potential differences, given conflicting results ...
Rein F. van Welie, Floor C. van Welie, Jennifer P. Trouerbach‐Kraan, Albert Dahan, Monique van Velzen, Gisela M. Terwindt   +5 more
wiley   +1 more source

Application of the augmented competing stimulus assessment to identify and establish competing self‐restraint items

Journal of Applied Behavior Analysis, Volume 59, Issue 1, Winter 2026.
Abstract Automatically maintained self‐injurious behavior (SIB) sometimes co‐occurs with self‐restraint, a self‐limiting behavior that impedes SIB and can be maladaptive (e.g., hinders functional skills and movement). The presence of self‐restraint suggests SIB produces aversive consequences, which self‐restraint limits.
Michelle A. Frank‐Crawford, Louis P. Hagopian, Jonathan D. Schmidt, Griffin W. Rooker, Drew E. Piersma, Ryan Benson   +5 more
wiley   +1 more source

Bedside Neuromodulation of Persistent Pain and Allodynia with Caloric Vestibular Stimulation

Biomedicines
Background: Caloric vestibular stimulation (CVS) is a well-established neurological diagnostic technique that also induces many phenomenological modulations, including reductions in phantom limb pain (PLP), spinal cord injury pain (SCIP), and central ...
Trung T. Ngo, Wendy N. Barsdell, Phillip C. F. Law, Carolyn A. Arnold, Michael J. Chou, Andrew K. Nunn, Douglas J. Brown, Paul B. Fitzgerald, Stephen J. Gibson, Steven M. Miller   +9 more
doaj   +1 more source

Spirulina platensis Attenuates Cold Allodynia and Chemical Allodynia in Streptozotocin induced Diabetic Rats

, 2023
Munmun Ghosh, Satabdi Ghosh, Taskina Ali, Nahida Sultana Nipa, Shuvajit Roy, Fadia Tasnim, Md Bulbul Hossain, Md. Mahbubur Rahman   +7 more
openalex   +2 more sources

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Manual Therapy in Conjunction With Other Multimodal Interventions in a Patient With Chronic Pain and Hypertension: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
Thoracic thrust manipulation. ABSTRACT Chronic pain and hypertension (HTN) are worldwide epidemics that are difficult to manage and frequently encountered as comorbid conditions in patient care. There is a paucity of information regarding the effect that manual therapy has on blood pressure (BP), particularly in those with chronic pain and HTN.
Craig P. Hensley, Renzo Mendoza, Jennifer Ryan, Emmanuel Yung   +3 more
wiley   +1 more source

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study elucidates the central role of transient receptor potential (TRP) channels in driving neuroinflammation across neurological disorders. Acting as critical molecular sensors on neurons and glial cells, TRP channels' activation initiates downstream pathways that promote the release of proinflammatory cytokines, a pathological mechanism in ...
Daji Guo, Mengjiao Cai, Yanmin Xian, Yinyin Chen, Yujun Feng, Chun Hu, Lizhang Zeng, Lei Shi, Shiqing Zhang   +8 more
wiley   +1 more source