Results 121 to 130 of about 57,089 (325)
TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha +9 more
wiley +1 more source
Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]
, 2018 The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A. +5 more
core +2 more sources
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective/Background This study was undertaken to assess participants' impression of use and satisfaction with STS101 in a long‐term, open‐label safety study. The ASCEND study assessed the safety and tolerability of STS101, an investigational drug–device combination of 5.2 mg dihydroergotamine in a single‐use nasal delivery device for the ...
Jessica Ailani +4 more
wiley +1 more source
Bilateral mechanical and thermal hyperalgesia and tactile allodynia after chronic compression of dorsal root ganglion in mice [PDF]
, 2011 Ronggui Chen +4 more
openalex +1 more source
Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors. [PDF]
, 2019 Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies.
Abrams, Gary +9 more
core
Headache: The Journal of Head and Face Pain, EarlyView.ABSTRACT Objective To explore the relationship between migraine attack onset in children and adolescents and Chinooks, which are dry and warm westerly winds that generally occur in the winter and bring about abrupt weather changes to the east of the Rocky Mountains in Southern Alberta, Canada. Methods This was a prospective longitudinal clinical cohort
Rylan Heart Villaruz +6 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background This study aimed to systematically review the literature and summarize, as well as quantitatively pool when feasible, longitudinal evidence regarding psychosocial predictors of headache chronification. Methods A comprehensive search was conducted in PubMed/MEDLINE, CINAHL, and PsycInfo.
Cornel H. M. Tol +4 more
wiley +1 more source
Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice
, 2020 Jacob R. Bumgarner +4 more
openalex +2 more sources
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective Examine treatment responses to and safety of onabotulinumtoxinA for the preventive treatment of chronic migraine (CM) among diverse racial groups. Background Evidence suggests there are differences in headache treatment patterns, symptom profiles, and burden based on race.
Andrew M. Blumenfeld +9 more
wiley +1 more source