Results 141 to 150 of about 52,858 (307)

Gαq signalling from endosomes: A new conundrum

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain

open access: yesJournal of Pain Research, 2017
Banulata Gopalsamy, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perimal Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang ...
Gopalsamy B   +4 more
doaj  

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. [PDF]

open access: yes, 2018
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and dose-limiting side effect of cancer treatment that affects millions of cancer survivors throughout the world and current treatment options are extremely limited by their side effects ...
Mackie, Ken   +6 more
core   +1 more source

Multielement Filament Memristor Enabling Multifunctional Neuromorphic Device

open access: yesAdvanced Functional Materials, Volume 35, Issue 24, June 19, 2025.
A new type of memristor featuring a hybrid mechanism and multifunctional applications is introduced. The proposed single device combines the alloy metal filament with the oxygen vacancy filament to achieve both resistive and threshold switching with enhanced reliability, mimicking both biological synapses and nociceptors. This study shows that filament‐
Mingu Jang   +4 more
wiley   +1 more source

Somatosensory and nociceptive changes in chronic post-stroke shoulder pain [PDF]

open access: yes, 2008
Preliminary results from a cross-sectional study that investigated the relation between the presence of post-stroke shoulder pain and somatosensory and nociceptive changes are presented.
Buitenweg, J.R.   +5 more
core   +1 more source

Optoelectronic Devices for In‐Sensor Computing

open access: yesAdvanced Materials, Volume 37, Issue 23, June 12, 2025.
The raw data obtained directly from sensors in the noisy analogue domain is often unstructured, which lacks a predefined format or organization and does not conform to a specific data model. Optoelectronic devices for in‐sensor visual processing can integrate perception, memory, and processing functions in the same physical units, which can compress ...
Qinqi Ren   +7 more
wiley   +1 more source

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman   +11 more
wiley   +1 more source

Pia Mater‐Penetrable Lipopolymer Nanoparticles for Gliocyte‐Targeted IL‐10 mRNA Therapy Alleviate Paclitaxel‐Induced Peripheral Neuropathy

open access: yesAdvanced Science, Volume 12, Issue 23, June 20, 2025.
The P6CIT lipopolymer demonstrates superior transfection efficacy in the spinal cord and DRG, as well as enhanced penetration of the pia mater compared to the MC3 ionizable lipid. Intrathecal delivery of P6CIT LPNPs enables effective transfection in the gliocytes in the spinal cord and DRG.
Xinrou Lin   +10 more
wiley   +1 more source

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