Results 141 to 150 of about 66,158 (349)

The pharmacotherapeutic potential of neuropeptide Y for chronic pain

Journal of Internal Medicine, EarlyView.
Abstract Chronic pain is a major medical problem that requires new therapeutic options. Discovered by Victor Mutt in 1982, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief. Genetic knockdown of NPY or pharmacological inhibition of its receptors demonstrates that NPY signaling tonically inhibits indices of chronic ...
Al A. Nie, Bradley K. Taylor
wiley   +1 more source

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]

, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai, BM Bradley, C Bourdon-Wouters, C Han, D Quan, DH Gilden, DW Wareham, Edward G. Rowan, EM Garry, Esther Grinfeld, Fiona Scott, FS Hasnie, FT Scott, G Ashrafi, G. H. Ashrafi, J Fogh, J Lai, JD Markman, JN Wood, Joseph Charles Glorioso, Judith Breuer, MA Hamza, MH Meisler, MJ Craner, MJ Quinlivan, ML Szpara, N Storey, Paul Montague, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PR Kinchington, R Dabby, R Mahalingam, RG Dalziel, RL Finnen, S Schünemann, SG Waxman, SJ Medhurst, SM Fleetwood-Walker, TR Cummins, W Peng, WA Catterall, X Zhou   +44 more
core   +3 more sources

The analgesic effect of intravenous methylprednisolone on acute neuropathic pain with allodynia due to central cord syndrome: a retrospective study

Journal of Pain Research, 2018
Liandong Li,1 Yawei Han,2 Tengshuai Li,1 Jiaming Zhou,1 Chao Sun,3,4 Yuan Xue1 1Department of Orthopaedics Surgery, Tianjin Medical University General Hospital, Tianjin, China; 2Department of Histology and Embryology, School of Basic Medical Sciences ...
Li L, Han Y, Li T, Zhou J, Sun C, Xue Y
doaj  

Neuromusculoskeletal ultrasound examination in Nicolau syndrome

PM&R, EarlyView.
Beytullah Yazar, Abdullah Emre Uğur, Mustafa Güngör Albayrak, Levent Özçakar   +3 more
wiley   +1 more source

Inside the Fire. Exploring the Impact of Anxiety, Depression, and Sleep Disturbances on Pain Perception in Burning Mouth Syndrome: A Cross‐Sectional Study of 200 Patients

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background This study investigates how anxiety, depression, and sleep disturbances affect pain perception and clinical impairment in burning mouth syndrome (BMS). Methods A cross‐sectional survey was conducted on 200 BMS patients. The Hamilton Rating Scale for Depression (HAM‐D) and Anxiety (HAM‐A), Epworth Sleepiness Scale (ESS), Pittsburgh ...
Antonietta Argiuolo, Federica Canfora, Benedetta Muzii, Cristina D'Antonio, Daniela D'Auria, Amerigo Giudice, Gennaro Musella, Luca D'Aniello, Massimo Aria, Nelson Mauro Maldonato, Michele Davide Mignogna, Daniela Adamo   +11 more
wiley   +1 more source

Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]

, 2006
BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore, Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Jones, Toni L, Rosengren, Sanna, Sorkin, Linda, Svensson, Camille I   +7 more
core   +3 more sources

A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats

BMC Complementary and Alternative Medicine, 2017
BackgroundThe current therapy of neuropathic pain is inadequate and is limited by the extent of pain relief and the occurrence of dose dependant side effects. Insufficient control of pain with conventional medications prompts the use of complementary and
M. Shahid, F. Subhan, Nisar Ahmad, Ihsan Ullah   +3 more
semanticscholar   +1 more source

Somatosensory and nociceptive changes in chronic post-stroke shoulder pain [PDF]

, 2008
Preliminary results from a cross-sectional study that investigated the relation between the presence of post-stroke shoulder pain and somatosensory and nociceptive changes are presented.
Buitenweg, J.R., Dongen, R.T.M. van, Geurts, A.C.H., IJzerman, M.J., Renzenbrink, G.J., Roosink, M.   +5 more
core   +1 more source

The Sympathetic Nervous System Contributes to Capsaicin-Evoked Mechanical Allodynia But Not Pinprick Hyperalgesia in Humans [PDF]

, 1996
Maywin Liu, Mitchell B. Max, Suzan Parada, Janet S. Rowan, Gary J. Bennett   +4 more
openalex   +1 more source

Administration of the Sleep‐Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia

Journal of Sleep Research, EarlyView.
ABSTRACT Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood.
Viviane S. Hambrecht‐Wiedbusch, Angelo V. Colmenero, Alejandra Mondino, Graciela Mentz, Steven E. Harte, Giancarlo Vanini   +5 more
wiley   +1 more source