Results 41 to 50 of about 32,744 (263)

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

Molecular Pain, 2011
Background Fibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established
Mukae Takehiro, Araki Kohei, Nagai Jun, Uchida Hitoshi, Nishiyori Michiko, Kishioka Shiroh, Ueda Hiroshi   +6 more
doaj   +1 more source

Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia Neurons

Toxins, 2020
Oxaliplatin is a third-generation platinum-based chemotherapeutic drug widely used in colorectal cancer treatment. Although potent against this tumor, it can induce cold and mechanical allodynia even after a single injection.
Ji Hwan Lee, Juan Gang, Eunhee Yang, Woojin Kim, Young-Ho Jin   +4 more
doaj   +1 more source

Hell's Itch: An Acute Reaction to Sunburn Exposure

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a neurocutaneous dysesthesia following sunburn that is underreported in scientific literature despite considerable discussion online. ‘Hell's itch’ describes an acute, uncontrollable itch with intense stabbing pain several days post‐sunburn and often follows an inciting event such as water exposure.
Colin Kelly, Connor Stonesifer, Brian W. Morrison   +2 more
wiley   +1 more source

A case of phantom pain and stump pain that was effectively controlled by ultrasound‐guided ulnar and median peripheral nerve blocks

Clinical Case Reports, 2023
Phantom limb pain and stump pain are often intractable, and their incidences are relatively high. We report a case of a patient with phantom limb and stump pain of the finger, who was successfully treated by peripheral nerve blocks.
Shunya Sekiguchi, Yusuke Ishida, Yosuke Fujita, Mikiko Tomino, Kiyoshige Ohseto   +4 more
doaj   +1 more source

Role of Gynecologic Findings in Interstitial Cystitis/Bladder Pain Syndrome: A Consensus

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To evaluate the role of gynecologic findings in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) by reviewing current international guidelines and identifying relevant gynecologic co‐morbidities. Methods This consensus statement was developed through a systematic four‐phase process: (1) comprehensive literature review across ...
Marie E. Sullivan, Amr El Haraki, Anna Padoa, Katy Vincent, Kristene E. Whitmore, Mauro Cervigni   +5 more
wiley   +1 more source

Clinical observation of the effect of prophylaxis on allodynia in patients with migraine

Journal of Pain Research, 2018
Na Zhang,1 Chun-Fu Chen2 1Department of Emergency Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China; 2Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China Objective: The
Zhang N, Chen CF
doaj  

The interaction of intrathecal neostigmine and N-cyclohexyladenosine on anti-allodynic effects in rats with a nerve ligation injury [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundNerve ligation injury in rats produces a pain syndrome that includes mechanical allodynia. Intrathecal administration of cholinesterase inhibitors or adenosine receptor agonists have anti-allodynic effects in this model.
Dae Kee Choi, Seong Soo Choi, Jai Hyun Hwang   +2 more
doaj   +1 more source

Integrated diagnostic approaches for superficial radial neuropathy: The role of ultrasonography in enhancing morphological assessments

PM&R, EarlyView.
Abstract Background Ultrasonography is useful for evaluating cutaneous nerve lesions. Objective To investigate the clinical utility of ultrasonography in accurately localizing nerve abnormalities in distal superficial radial neuropathy, based on clinical symptoms and electrodiagnostic test results. Design Retrospective descriptive study.
Hong Bum Park, Young Kwang Choi, Jong Chan Lim, Dong Hwee Kim   +3 more
wiley   +1 more source