Results 61 to 70 of about 66,158 (349)
Migraine-provoking substances evoke periorbital allodynia in mice
The Journal of Headache and Pain, 2019 BackgroundAdministration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks.
Francesco De Logu +6 more
semanticscholar +1 more source
BiomedicinesA complication of diabetes is neuropathic pain, which is difficult to control with medication. We have confirmed that neuropathic pain due to mechanical allodynia in diabetic mice is mediated by a characteristic neuropeptide in the spinal cord.
Takafumi Hayashi +8 more
doaj +1 more source
Pharmaceuticals, 2023 The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed.
Nariman Essmat +13 more
doaj +1 more source
Brain : a journal of neurology, 2019 Cranial allodynia associated with spontaneous migraine is reported as either responsive to triptan treatment or to be predictive of lack of triptan efficacy.
S. Akerman +6 more
semanticscholar +2 more sources
Clinical Case Reports, 2023 Phantom limb pain and stump pain are often intractable, and their incidences are relatively high. We report a case of a patient with phantom limb and stump pain of the finger, who was successfully treated by peripheral nerve blocks.
Shunya Sekiguchi +4 more
doaj +1 more source
Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models
Frontiers in Pain Research, 2023 Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the main
Ariadni Bella +11 more
doaj +1 more source
Molecules, 2019 Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs), therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available drugs.
E. Aly, Maitham A. Khajah, W. Masocha
semanticscholar +1 more source
Advanced Science, EarlyView.β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong +15 more
wiley +1 more source
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler +9 more
core +3 more sources
Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone
Frontiers in Cellular Neuroscience, 2014 A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor ...
Pierrick ePoisbeau +6 more
doaj +1 more source