Results 61 to 70 of about 415,260 (411)

Donor selection for allogenic hemopoietic stem cell transplantation: clinical and ethical considerations [PDF]

, 2017
Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood.
La Russa, Raffaele, Liso, Arcangelo, Pascale, Natascha, Riezzo, Irene, Salerno, Monica, Turillazzi, Emanuela   +5 more
core   +4 more sources

Lovo‐cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB‐206 study

American Journal of Hematology, Volume 98, Issue 1, Page 11-22, January 2023., 2023
Treatment process evolution. *The target TNC for BMH was ≥6 × 108/kg per patient. The Group B1 patient received lovo‐cel produced using both the original and refined manufacturing process, and the Group B2 patient received lovo‐cel produced using only the refined manufacturing process.
Julie Kanter, Alexis A. Thompson, Francis J. Pierciey Jr, Matthew Hsieh, Naoya Uchida, Philippe Leboulch, Manfred Schmidt, Melissa Bonner, Ruiting Guo, Alex Miller, Jean‐Antoine Ribeil, David Davidson, Mohammed Asmal, Mark C. Walters, John F. Tisdale   +14 more
wiley   +1 more source

Risk factors for relapse after allogeneic transplantation in acute myeloid leukemia

Haematologica, 2016
Acute myeloid leukemia is a clonal neoplasm derived from myeloid progenitor cells with a varying outcome. The initial goal of treatment is the achievement of complete remission, defined for over 40 years by morphology.
Gert J. Ossenkoppele, Jeroen J.W.M. Janssen, Arjan A. van de Loosdrecht   +2 more
doaj   +1 more source

Risk for Clostridium difficile infection after allogeneic hematopoietic cell transplant remains elevated in the postengraftment period [PDF]

, 2017
BACKGROUND: Clostridium difficile infection (CDI) is a frequent cause of diarrhea among allogeneic hematopoietic cell transplant (HCT) recipients. It is unknown whether risk factors for CDI vary by time posttransplant.
Bommarito, Kerry M, Chiller, Tom M, DiPersio, John, Dubberke, Erik R, Fraser, Victoria J, Olsen, Margaret A, Reske, Kimberly A, Seiler, Sondra, Silveira, Fernanda P   +8 more
core   +2 more sources

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD.

Blood, 2016
The development and maintenance of immune tolerance after allogeneic hematopoietic stem cell transplantation (HSCT) requires the balanced reconstitution of donor-derived CD4 regulatory T cells (CD4Tregs) as well as effector CD4 (conventional CD4 T cells [
A. Alho, Haesook T. Kim, Marie J Chammas, Carol G. Reynolds, T. R. Matos, Edouard Forcade, J. Whangbo, S. Nikiforow, C. Cutler, J. Koreth, V. Ho, P. Armand, J. Antin, E. Alyea, J. Lacerda, R. Soiffer, J. Ritz   +16 more
semanticscholar   +1 more source

Cutaneous T‐cell lymphomas: 2023 update on diagnosis, risk‐stratification, and management

American Journal of Hematology, Volume 98, Issue 1, Page 193-209, January 2023., 2023
Abstract Disease Overview Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). Diagnosis The diagnosis of MF or SS requires the integration of clinical and histopathologic data.
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source

Impact of different post-remission strategies on quality of life in patients with acute myeloid leukemia

Haematologica, 2008
Background The impact on quality of life of allogeneic stem cell transplantation or conventional chemotherapy in patients with acute myeloid leukemia remains unclear, mainly because of a lack of studies with long-term follow-up. The German AML-Intergroup,
Dorle Messerer, Jutta Engel, Joerg Hasford, Markus Schaich, Gerhard Ehninger, Cristina Sauerland, Thomas Büchner, Andrea Schumacher, Rainer Krahl, Dietger Niederwieser, Jürgen Krauter, Arnold Ganser, Ursula Creutzig, Hartmut Döhner, Richard F. Schlenk   +14 more
doaj   +1 more source

Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness in Clinical Outcomes Following Stem Cell Transplantation [PDF]

PLoS One. 2017 Dec 1;12(12):e0187771, 2016
Alloreactivity following stem cell transplantation (SCT) is difficult to predict in patients undergoing transplantation from HLA matched donors. In this study we performed whole exome sequencing of SCT donor-recipient pairs (DRP). This allowed determination of entire library of alloreactive peptide sequences which would bind HLA class I molecules in ...
arxiv   +1 more source

Survival Prediction of Children Undergoing Hematopoietic Stem Cell Transplantation Using Different Machine Learning Classifiers by Performing Chi-squared Test and Hyper-parameter Optimization: A Retrospective Analysis [PDF]

, 2022
Bone Marrow Transplant, a gradational rescue for a wide range of disorders emanating from the bone marrow, is an efficacious surgical treatment. Several risk factors, such as post-transplant illnesses, new malignancies, and even organ damage, can impair long-term survival. Therefore, technologies like Machine Learning are deployed for investigating the
arxiv   +1 more source

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel [PDF]

, 2020
No biomarker panel is established for prediction of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), a major complication of allogeneic stem cell transplantation (alloSCT).
Blau, Igor W., Bullinger, Lars, Dreger, Peter, Jiang, Sihe, Luft, Thomas, Majer-Lauterbach, Joshua, Müller-Tidow, Carsten, Penack, Olaf, Radujkovic, Aleksandar, Schult, David, Terzer, Tobias   +10 more
core   +3 more sources