Results 61 to 70 of about 166,368 (358)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]

, 2005
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Assenmacher, Mario, Billingham, Lucinda, Chakraverty, Ronjon, Cobbold, Mark, Craddock, Charles, Crawley, Charles, Goldman, John, Khan, Naeem, Mahendra, Premini, McDonald, Dorothy, Moss, Paul A. H., Olavarria, Eduardo, Osman, Husam, Pourgheysari, Batoul, Steward, Colin, Tauro, Sudhir   +15 more
core   +6 more sources

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro

Molecular Therapy: Nucleic Acids
Antisense oligonucleotides (ASOs), including splice-switching oligonucleotides (SSOs), are promising therapeutic approaches for targeting genetic defects.
H. Yesid Estupiñán, Tom Baladi, Samantha Roudi, Michael J. Munson, Jeremy Bost, Oskar Gustafsson, Daniel Velásquez-Ramírez, Deepak Kumar Bhatt, Daniel Hagey, Dennis Hekman, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén   +12 more
doaj   +1 more source

Immune recognition surface construction of Mycobacterium tuberculosis epitope-specific antibody responses in tuberculosis patients identified by peptide microarrays

International Journal of Infectious Diseases, 2017
Background: Understanding of humoral immune responses in tuberculosis (TB) is gaining interest, since B-cells and antibodies may be important in diagnosis as well as protective immune responses.
Davide Valentini, Martin Rao, Giovanni Ferrara, Marc Perkins, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer   +6 more
doaj   +1 more source

Effect of HLA Mismatch on Post-Transplant Infections in Allogeneic Hematopoietic Stem Cell Transplantation with PTCy-Based GvHD Prophylaxis [PDF]

, 2023
John Donald Marra, Eugenio Galli, Sabrina Giammarco, Patrizia Chiusolo, Elisabetta Metafuni, Federica Sorà, Luca Laurenti, Idanna Innocenti, Francesco Autore, Maria Assunta Limongiello, Alberto Fresa, Andrea Bacigalupo, Simona Sica   +12 more
openalex   +1 more source

Costimulatory molecule-deficient dendritic cell progenitors (MHC class II⁺, CD80(dim), CD86^-) prolong cardiac allograft survival in nonimmunosuppressed recipients [PDF]

, 1996
We have shown previously that granulocyte-macrophage colony-stimulating factor-stimulated mouse bone marrow-derived MHC class II+ dendritic cell (DC) progenitors that are deficient in cell surface expression of the costimulatory molecules B7-1 (CD8O) and
Angus W. Thomson, Azuma, Boussiotis, Boussiotis, Clare-Salzler, Demetris, Frances Chambers, Freeman, Freeman, Fumin Fu, Gimmi, Go, Hathcock, Inaba, Inaba, Inaba, Jenkins, Jenkinson, John J. Fung, Khoury, Kraal, Larsen, Lin, Lina Lu, Linsley, Lu, Lu, Lu, Lu, Matzinger, Pearson, Qian, Rastellini, Reis e Sousa, Sakamoto, Sayegh, Shiguang Qian, Starzl, Starzl, Steinman, Swiggard, Talmor, Taniguchi, Thomas E. Starzl, Thomson, Turka, Van Gool, Woo, Youping Li   +48 more
core   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source