Results 41 to 50 of about 10,309 (223)

TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA.

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Context and Objectives: Blood transfusions (BT) remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. We aim to assess infectious markers, red cell alloimmunization and iron overload secondary
Moussa Seck, Alioune Badara Senghor, Mossane Loum, Sokhna Aissatou Touré, Blaise Félix Faye, Alioune Badara Diallo, Mohamed Keita, Elimane Seydi Bousso, Sérigne Mourtalla Guèye, Macoura Gadji, Abibatou Sall, Awa Oumar Touré, Saliou Diop   +12 more
doaj   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Risk factors for alloimmunization by patients with sickle cell disease

Brazilian Journal of Medical and Biological Research, 2005
Blood transfusion in patients with sickle cell disease (SCD) is limited by the development of alloantibodies to erythrocytes. In the present study, the frequency and risk factors for alloimmunization were determined.
M. Murao, M.B. Viana
doaj   +1 more source

Routine Fetal Rhd Genotyping with Maternal Plasma: A Four-Year Experience in Belgium [PDF]

, 2008
peer reviewedBACKGROUND: The objective was to evaluate the diagnostic value of RHD fetal genotyping from the plasma of D- mothers as soon as 10 weeks' gestation in a routine clinical practice in Belgium.
Bianchi DW, Colin Y, Cortey A, Daniels G, Flegel WA, Flegel WA, Grootkerk MG, Judd WJ, Legler J, Mannessier L, Minon JM, Moise KJ, Moise KJ, Singleton BK, Wagner FF, Wagner FF   +15 more
core   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome

Haematologica, 2017
Up to 90% of patients with a myelodysplastic syndrome require red blood cell transfusion; nevertheless, comprehensive data on red cell alloimmunization in such patients are limited.
Deepak Singhal, Monika M. Kutyna, Rakchha Chhetri, Li Yan A. Wee, Sophia Hague, Lakshmi Nath, Shriram V. Nath, Romi Sinha, Nicholas Wickham, Ian D. Lewis, David M. Ross, Peter G. Bardy, Luen Bik To, John Reynolds, Erica M. Wood, David J. Roxby, Devendra K. Hiwase   +16 more
doaj   +1 more source

Trends of Erythrocyte Alloimmunization in Transfused Women

Pakistan Armed Forces Medical Journal, 2022
Objective: To identify the trends of red cell alloimmunization in multi-transfused females using red blood cell panels. Study design: Cross-sectional study.
Sunia Ghaffar, Nasir Uddin, Samia Ghaffar, Hala Haq, Izza Nawab, Bushra Ghaffar   +5 more
doaj   +1 more source

The molecular basis of RH system and its applications in obstetrics and transfusion medicine [PDF]

, 2010
The Rh system is the most polymorphic and immunogenic for all blood group systems. Currently more than 49 antigens were identified with five major antigens D, C, c, E, e. Knowledge of the Rh system's molecular basis, since its first cloning 17 years ago,
Araujo Júnior, Edward, Barreto, Jose Augusto, Moron, Antonio Fernandes, Nardozza, Luciano Marcondes Machado, Szulman, Alexandre   +4 more
core   +3 more sources

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

Hemolytic disease of newborn following anti-C and anti-S alloimmunization: A case report with review of literature

Indian Pediatrics Case Reports, 2023
Background: Non-Rhesus D antigen non-ABO, minor blood group alloimmunization in pregnant women is being increasingly recognized as a significant contributor to the development of the hemolytic disease of the fetus and newborn (HDFN).
Shrutiprajna Kar, Monalisa Pradhan, Tapas Som, Pankaj Kumar Mohanty   +3 more
doaj   +1 more source