Results 51 to 60 of about 10,210 (217)

Safer Access With Fewer Transfusions: Revisiting Platelet Thresholds in Pediatric Central Venous Catheterization

European Journal of Haematology, EarlyView.
ABSTRACT Background Central venous catheters (CVCs) are essential in pediatric hematology‐oncology, for the administration of chemotherapy and supportive therapy. Thrombocytopenia increases the risk of bleeding and current guidelines recommend prophylactic platelet transfusions below 40–50 × 109/L, though evidence is limited and transfusions entail ...
Alessandro Raffaele, Carlo Maria Ferlini, Marta Gazzaneo, Piero Giovanni Romano, Bilge Rol, Francesco Delle Cave, Stella Boghen, Tommaso Mina, Marco Zecca   +8 more
wiley   +1 more source

The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice

EBioMedicine, 2016
Red blood cell (RBC) transfusions are essential for patients with hematological disorders and bone marrow failure syndromes. Despite ABO matching, RBC transfusions can lead to production of alloantibodies against “minor” blood group antigens.
David R. Gibb, Samuele Calabro, Dong Liu, Christopher A. Tormey, Steven L. Spitalnik, James C. Zimring, Jeanne E. Hendrickson, Eldad A. Hod, Stephanie C. Eisenbarth   +8 more
doaj   +1 more source

Plasmapheresis for the Treatment of Anti-M Alloimmunization in Pregnancy

Case Reports in Obstetrics and Gynecology, 2020
Intrauterine transfusion is the standard antenatal treatment for a fetus with severe anemia. Plasmapheresis is an alternative treatment for cases with a history of severe hemolytic disease of the fetus and newborns at less than 20 weeks of gestation ...
Yohei Maki, Junko Ushijima, Seishi Furukawa, Hiroko Inagaki, Hiroyuki Takenouchi, Shouichi Fujimoto, Hiroshi Sameshima   +6 more
doaj   +1 more source

Evaluation of the New Lateral Flow Card MDmulticard® Basic Extended Phenotype in Routine Clinical Practice [PDF]

, 2018
Background: Transfusion emergencies and critical situations require specifically designed devices to simplify and optimize the standard procedures. In addition, matching antigens over and above ABO-Rh-K would be beneficial. Methods: Routine blood samples
Candela-García, María-José, Manteau, Annie-Claude, Mayer, Beate, Müller, Julia, Pruß, Axel, Weinstock, Christof   +5 more
core   +1 more source

Estimating Causal Effects of Third‐Stage Management on Postpartum Haemorrhage in a Midwifery Context: An Evidence Synthesis Approach for Constructing Directed Acyclic Graphs

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Estimating the causal effect of third‐stage management approaches on preventing postpartum haemorrhage (PPH) in the context of physiologic birth using observational data requires conditioning on specific variables, with selection relying on assumptions about their roles in the exposure‐outcome pathway that are rarely made explicit ...
Vanessa Hébert, Irina I. Oltean, Giulia M. Muraca, Nancy Santesso, Elizabeth K. Darling   +4 more
wiley   +1 more source

Evidence for a regulatory idiotypic network in the in vivo response to H-2 antigens. [PDF]

, 1985
Treatment of BALB/c mice with purified pig antiidiotype to 11-4.1 (anti-H-2Kk) monoclonal antibody has been found previously to induce the appearance of idiotype-bearing molecules (Id') in the serum of these mice, in the absence of detectable antigen ...
Bluestone, JA, Rabinowitz, R, Sachs, DH
core  

Delayed hemolytic transfusion reaction presenting as a painful crisis in a patient with sickle cell anemia [PDF]

, 1999
CONTEXT: Patients with sickle cell anemia (SCA) are frequently transfused with red blood cells (RBC). Recently, we reported that the calculated risk of RBC alloimmunization per transfused unit in Brazilian patients with SCA is 1.15%.
Bordin, Jose Orlando, Fabron Junior, Antonio, Moreira Junior, Gilberto   +2 more
core   +2 more sources

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

Trends of Erythrocyte Alloimmunization in Transfused Women

Pakistan Armed Forces Medical Journal, 2022
Objective: To identify the trends of red cell alloimmunization in multi-transfused females using red blood cell panels. Study design: Cross-sectional study.
Sunia Ghaffar, Nasir Uddin, Samia Ghaffar, Hala Haq, Izza Nawab, Bushra Ghaffar   +5 more
doaj   +1 more source

Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies

Transfusion, EarlyView.
Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson   +33 more
wiley   +1 more source