Results 151 to 160 of about 61,179 (292)

Analytical method development and validation of allopurinol and related substances by using RP-HPLC in bulk form

, 2022
P. Rajavenkata Prasad, Dasa Karunakar, B. Rama Devi   +2 more
openalex   +1 more source

Association between allopurinol and cardiovascular outcomes and all‐cause mortality in diabetes: A retrospective, population‐based cohort study

Diabetes, obesity and metabolism, 2019
To assess the association between allopurinol and mortality and cardiovascular outcomes in an allopurinol‐treated diabetes cohort.
A. Weisman, G. Tomlinson, L. Lipscombe, B. Perkins, G. Hawker   +4 more
semanticscholar   +1 more source

Effectiveness of Allopurinol on Uric Acid and Pediatric Chronic Kidney Disease Severity in the Chronic Kidney Disease in Children Study

Kidney Medicine
Rationale & Objective: Clinical trials have shown that serum uric acid reduction does not slow chronic kidney disease (CKD) progression in adults, but it is uncertain whether these findings apply to children.
Derek K. Ng, Matthew B. Matheson, George J. Schwartz, Katherine E. Kurgansky, Bradley A. Warady, Susan L. Furth   +5 more
doaj   +1 more source

Effect of Allopurinol in Decreasing Proteinuria in Type 2 Diabetic Patients [PDF]

, 2010
Introduction. Diabetic nephropathy is the most prevalent cause of end-stage renal disease. Besides factors such as angiotensin II, cytokines, and vascular endothelial growth factor, uric acid may play a role as the underlying cause of diabetic ...
Kheiri, Soleiman., Momeni, Ali., Seirafian, Shiva., Shahidi, Shahrzad., Taheri, Shahram.   +4 more
core  

Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS Syndrome) Manifesting With Pseudolymphoma Multisystemic Organ Involvement

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Drug reaction with Eosinophilia and Systemic Symptoms is a rare significant cutaneous adverse reaction with associated mortality. Extensive pseudolymphomatous multiorgan manifestations with prolonged latency from nonsteroidal anti‐inflammatory exposure highlight the clinical spectrum and severity.
Hilary Regan, Gerard O. Sullivan, Pauline Marren   +2 more
wiley   +1 more source

Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells.

PLoS ONE
Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis.
Karel H van der Pol, Jan Koenderink, Jeroen J M W van den Heuvel, Petra van den Broek, Janny Peters, Imke D W van Bunningen, Jeanne Pertijs, Frans G M Russel, Jim Koldenhof, Wim J Morshuis, Joris van Drongelen, Tom J J Schirris, Andries van der Meer, Gerard A Rongen   +13 more
doaj   +1 more source

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 89-100, January 2026.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Antioxidant activity of allopurinol on copper‐catalysed human lipoprotein oxidation [PDF]

, 1997
Domenico Lapenna, Sergio de Gioia, Giuliano Ciofani, Franco Cuccurullo   +3 more
openalex   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Association between allopurinol and hepatocellular carcinoma: analysis of genetic risk and patient survival

Discover Oncology
Background Despite the widespread clinical use of allopurinol for managing hepatocellular carcinoma (HCC) and gout, its potential hepatotoxicity and its effect on the risk of HCC remain unclear.
Yu-fu Li, Hui-wei Wang, Huan-yan Peng, Zhen-ying Zhang, Zhi-jia Yao, Yuan Meng, Dong-ye Yang   +6 more
doaj   +1 more source