Results 161 to 170 of about 61,179 (292)

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source

Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley   +1 more source

Development of Hyperuricemia and Hyperglycemia After Prolonged Consumption of Clams (Galatea paradoxa) at the Recommended Daily Allowance

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Prolonged consumption of clam, Galatea paradoxa, powder led to dose‐dependent increases in uric acid and blood glucose in rats. Liver weight decreased at the highest dose, accompanied by mild histological alterations. These findings suggest that high clam intake, even within recommended dietary levels, may contribute to metabolic disturbances ...
Samuel Adjei, Matilda Asante, Charles Mills‐Robertson, Samkeliso Takaidza, Vivash Naidoo, Perpetua Dagadu, Stephen Yormasah, Ruth Owu, George A. Asare   +8 more
wiley   +1 more source

Anti‐Tubercular Drug‐Induced Liver Injury: Current Understanding and Emerging Directions

JGH Open, Volume 10, Issue 1, January 2026.
ABSTRACT Most common adverse effect causing cessation of anti‐tubercular treatment (ATT) is drug‐induced liver injury (DILI) which is unpredictable due to its idiosyncratic nature. ATT is the most common cause of DILI and drug‐induced acute liver failure (ALF) in South East Asia.
Shubham Prasad, Himanshu Narang, Saurabh Kedia, Vineet Ahuja   +3 more
wiley   +1 more source

Allopurinol-Induced Oral Lichenoid Drug Reaction with Complete Regression after Drug Withdrawal [PDF]

, 2020
Alexandre Perez, Benjamin Lazzarotto, Jean‐Pierre Carrel, Tommaso Lombardi   +3 more
openalex   +1 more source

Pharmacogenomic Calling From Whole‐Exome Sequencing in the Taiwanese Population—A Real‐World Experience

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Hsu‐Heng Lin, Meng‐Ju Melody Tsai, Hui‐An Chen, Rai‐Hseng Hsu, Yun‐Syuan Lin, Yi‐Lin Lin, Ching Hsu, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Ni‐Chung Lee   +9 more
wiley   +1 more source

P456 Drug survival of thiopurine–allopurinol combination therapy in a real-life population-based cohort [PDF]

, 2018
Joany E. Kreijne, Rozanne C. de Veer, Nanne K.H. de Boer, Xiong Ma, Gerard Dijkstra, Rachel West, Ad A. van Bodegraven, Dirk J. de Jong, C. Janneke van der Woude, Annemarie C. de Vries   +9 more
openalex   +1 more source

Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project

Diabetic Medicine, Volume 43, Issue 1, January 2026.
Abstract Aims Diabetes is characterized by clinical heterogeneity. This study aimed to identify different clinical phenotypes of real‐world people with diabetes and to assess their associations with major adverse cardiovascular events (MACEs). Methods From a prospective Polish registry of people with diabetes, hierarchical cluster analysis was ...
Marta Mantovani, Hanna Kwiendacz, Krzysztof Irlik, Tommaso Bucci, Mirela Hendel, Steven H. M. Lam, Bi Huang, Paulina Szromek‐Białek, Monika Niezgoda, Uazman Alam, Giuseppe Boriani, Janusz Gumprecht, Gregory Y. H. Lip, Katarzyna Nabrdalik   +13 more
wiley   +1 more source

Myasthenia Gravis Outcomes After Use of Statins and Other Contraindicated Treatments: Results From the French National Insurance Database

European Journal of Neurology, Volume 33, Issue 1, January 2026.
In this real‐world study among 14,459 adults with MG, exposure to any contraindicated treatment was not significantly associated with risk of ICU admission for MG but was associated with significantly higher risk of death. In contrast, statins were associated with a greater risk of ICU admission but a lower risk of death.
Guilhem Solé, Jean Philippe Camdessanché, Shahram Attarian, Mariana Ciumas, Cécile Blein, Benjamin Grenier, Eléonore Herquelot, Andoni Echaniz‐Laguna   +7 more
wiley   +1 more source

Allopurinol administered prior to hepatic ischaemia in the rat prevents chemiluminescence following restoration of circulation [PDF]

, 1992
Peter J. Cohen
openalex   +1 more source