Results 151 to 160 of about 3,437 (186)
Allorecognition Maturation in the Broadcast-Spawning Coral Acropora millepora
Many sessile marine invertebrates discriminate self from non-self with great precision, but maturation of allorecognition generally takes months to develop in juveniles.
Bette L Willis +2 more
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Current Opinion in Nephrology and Hypertension, 1993
Understanding the nature of allorecognition is fundamental to the design of antigen-specific therapies for transplantation. As recently as 10 years ago it was generally believed that recognition of major histocompatibility complex (MHC) molecules by T lymphocytes was direct and represented the "simplest" kind of T-lymphocyte interaction.
A M, Krensky, C, Clayberger
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Understanding the nature of allorecognition is fundamental to the design of antigen-specific therapies for transplantation. As recently as 10 years ago it was generally believed that recognition of major histocompatibility complex (MHC) molecules by T lymphocytes was direct and represented the "simplest" kind of T-lymphocyte interaction.
A M, Krensky, C, Clayberger
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The Hydractinia allorecognition system
Immunogenetics, 2021Hydractinia symbiolongicarpus is a colonial hydroid and a long-standing model system for the study of invertebrate allorecognition. The Hydractinia allorecognition system allows colonies to discriminate between their own tissues and those of unrelated conspecifics that co-occur with them on the same substrate.
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The Molecular Basis of Allorecognition
Annual Review of Immunology, 1993Until recently it was generally assumed that the focus of T cell receptor recognition of allogeneic MHC molecules was the polymorphic regions on the molecule that differed between responder and stimulator. It is now clear that all T cell recognition, including self-tolerance and allorecognition, involves both the MHC molecule and its associated peptide
L A, Sherman, S, Chattopadhyay
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Direct and Indirect Allorecognition
Methods in Molecular Biology, 2006The design and effectiveness of strategies to promote long-term graft acceptance requires a fundamental understanding of the mechanisms underlying acute and chronic rejection. This chapter discusses the two pathways of allorecognition--direct and indirect--and suggests that the direct pathway plays a major role in the early weeks after transplantation ...
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Molecular Mechanisms of Allorecognition in a Basal Chordate [PDF]
Allorecognition has been described in many metazoan phyla, from the sponges to the mammals. In vertebrates, allorecognition is a result of a MHC-based recognition event central to adaptive immunity. However, the origin of the adaptive immune system and the potential relationship to more primitive allorecognition systems is unclear.
Anthony W De Tomaso
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Structural aspects of allorecognition
Current Opinion in Immunology, 1991The phenomenon of T-cell allorecognition of foreign major histocompatibility molecules has been one of the more enigmatic aspects of T-cell immunology. The molecular basis for allorecognition is unfolding as a result of the application of major histocompatibility complex structure/function analyses in the light of current insights into the three ...
R, Lechler, G, Lombardi
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Allorecognition in compound ascidians
The International Journal of Developmental Biology, 1994In botryllids (colonial ascidians), there are two types of allorecognition: colony specificity and colony resorption. Colony specificity is manifested by fusion and rejection between two conspecific colonies. The genetic basis for this colony specificity resides in a single highly polymorphic gene locus (fusibility locus) with codominantly expressed ...
Y, Saito, E, Hirose, H, Watanabe
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Role of Indirect Allorecognition in Allograft Rejection
International Reviews of Immunology, 1996It is now clear from animal studies that indirect allorecognition occurs during allograft rejection and that this pathway plays a role in mediating the rejection process. Whether this pathway is the dominant pathway responsible for chronic rejection remains to be established, but this is an intriguing hypothesis that may have major implications for ...
Mohamed H Sayegh +2 more
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Hierarchical Contributions of Allorecognition Pathways in Chronic Lung Rejection. [PDF]
The role of allorecognition in initiating lung graft rejection is not clearly defined. Using the heterotopic tracheal transplantation model, we examined the contributions of the indirect and direct allorecognition pathways in chronic airway rejection ...
Scott H Randell +2 more
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