Results 161 to 170 of about 3,437 (186)
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Tolerogenic response: Allorecognition pathways
Transplant Immunology, 2006The induction of immune tolerance in transplant recipients has been sought for many years but only a fundamental understanding of the immunological mechanisms underlying graft rejection will allow manipulation of the anti-graft immune response. In general, acute rejection is better understood and treated than chronic rejection, as they occur through ...
A, Caballero +5 more
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Indirect Allorecognition: Not Simple but Effective
Transplantation, 2008Donor dendritic cells are potent but short-lived stimulators of early transplant rejection, and recipient antigen presenting cells presenting donor major histocompatibility complex peptides sustain immunoreactivity and contribute to chronic rejection.
Eleanor M, Bolton +2 more
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Involvement of the CDw50 molecule in allorecognition
Tissue Antigens, 1990Abstract: The CDw50 differentiation antigen is defined by 101–1D2 and 140–11 monoclonal antibodies (mAb), both produced and characterized in our laboratory. This molecule is broadly expressed on hematopoetic cells but not on other cells. In this report we show that these 2 mAb recognize different epitopes of the same molecule, which are resistant to ...
R, Vilella +5 more
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Pathways of Allorecognition: Implications for Transplantation Tolerance
Transplant Immunology, 2002Allorecognition occurs when the host immune system detects same-species, non-self antigens and this is the trigger for allograft rejection. Host T cells detect these 'foreign' antigens which are mostly derived from a highly polymorphic region of the genome called the major histocompatibility complex.
Robert I Lechler
exaly +3 more sources
2004
Allorecognition refers to detection by the immune system of genetically encoded polymorphisms between members of the same species. Following transplantation of allogeneic tissues, recognition by recipient T lymphocytes of foreign proteins expressed by donor cells (T-cell allorecognition) initiates a cascade of immunological reactions resulting in rapid
Gilles Benichou +4 more
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Allorecognition refers to detection by the immune system of genetically encoded polymorphisms between members of the same species. Following transplantation of allogeneic tissues, recognition by recipient T lymphocytes of foreign proteins expressed by donor cells (T-cell allorecognition) initiates a cascade of immunological reactions resulting in rapid
Gilles Benichou +4 more
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Allorecognition in biological systems
Developmental & Comparative Immunology, 1981Abstract Colonial marine organisms of several phyla show the capacity for allogeneic recognition and response. In the colonial tunicate Botryllus , colony fusibility characteristics are determined by a single Mendelian locus with multiple co-dominant alleles.
Virginia L. Scofield, Irving L. Weissman
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The structural basis of T‐cell allorecognition
Tissue Antigens, 2004Abstract: Foreign allogeneic major histocompatibility complex (MHC) class I and class II molecules elicit an exceptionally vigorous T‐cell response. A small component of the alloresponse comprises CD4+ T cells that recognize allogeneic MHC indirectly after processing into peptide fragments that are bound and presented by self‐MHC class II.
Whitelegg, A, Barber, L D
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Allorecognition Pathways in Transplant Rejection and Tolerance
Transplantation, 2013With the advent of cellular therapies, it has become clear that the success of future therapies in prolonging allograft survival will require an intimate understanding of the allorecognition pathways and effector mechanisms that are responsible for chronic rejection and late graft loss.Here, we consider current understanding of T-cell allorecognition ...
Jason M, Ali +3 more
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The Evolution of Allorecognition Specificity
1988Intraspecific aggression between clonal cnidarians is not random with respect to genotype; instead, agonistic behavior is modified according to the relatedness of contestants such that clonemates and close relatives behave passively, whereas more distant relatives behave aggressively.
Richard K. Grosberg, James F. Quinn
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