Results 181 to 190 of about 692,160 (279)

Identification of Sulfonamide-Vinyl Sulfone/Chalcone and Berberine-Cinnamic Acid Hybrids as Potent DENV and ZIKV NS2B/NS3 Allosteric Inhibitors. [PDF]

Int J Mol Sci
Mahalapbutr P, Hengphasatporn K, Manimont W, Vajarintarangoon L, Shigeta Y, Bhat N, Aiebchun T, Nutho B, Hannongbua S, Rungrotmongkol T.   +9 more
europepmc   +1 more source

Application of particle swarm optimization to understand the mechanism of action of allosteric inhibitors of the enzyme HSD17β13. [PDF]

Patterns (N Y), 2023
Ford A, Breitgoff F, Pasquini M, MacKenzie A, McElroy S, Baker S, Abrusci P, Varzandeh S, Bird L, Gavard A, Damerell D, Redhead M.   +11 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Selective STAT3 Allosteric Inhibitors HCB-5300 and HCB-5400 Alleviate Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. [PDF]

Int J Mol Sci
Baek WY, Kim JW, Park SW, Kim N, Lim SG, Suh CH.   +5 more
europepmc   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. [PDF]

Mol Metab
Bowman CE, Neinast MD, Kawakami R, Forelli N, Jang C, Patel J, Blair MC, Noji MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z.   +15 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development. [PDF]

ACS Omega
Hernandez I, Jin KC, Yang Y, Konttinen O, Lantz A, Zhao Y, Squire I, Pettus TRR, Reich NO.   +8 more
europepmc   +1 more source

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Targeting SHP2 with Natural Products: Exploring Saponin-Based Allosteric Inhibitors and Their Therapeutic Potential. [PDF]

Curr Issues Mol Biol
Moon DO.
europepmc   +1 more source