Results 51 to 60 of about 1,267 (159)
A Simplified Quantitative Real-Time PCR Assay for Monitoring SARS-CoV-2 Growth in Cell Culture
mSphere, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions within just a few months, causing severe respiratory disease and mortality. Assays to monitor SARS-CoV-2 growth in vitro depend on time-consuming and costly RNA extraction
Christian Shema Mugisha +11 more
doaj +1 more source
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, Volume 90, Issue 12, December 10, 2025.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.Diverse small‐molecule condensate‐modifying therapeutics (c‐mods) engage condensates through π–π stacking, cation–π, hydrogen bonding, and electrostatic contacts to selectively dissolve pathological assemblies or stabilize functional condensates. Highlighted aromatic cores and polar substituents mediate specific interactions, while counter‐anion ...
Abdurrahman Usman +4 more
wiley +1 more source
Advanced Theory and Simulations, Volume 8, Issue 7, July 2025.The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak +2 more
wiley +1 more source
Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages
Advanced Therapeutics, Volume 8, Issue 4, April 2025.Tackling the problem of tuberculosis (TB) and human immunodeficiency virus (HIV) co‐infection is a serious global health concern affecting people of all ages. This review presents the characteristics of both diseases, current treatment and diagnostic guidelines, associated problems, innovations in disease management, and overall effects on global ...
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
wiley +1 more source
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source
Ibrain, Volume 10, Issue 4, Page 395-426, Winter 2024.This review elucidates the pivotal role of RNA modifications in the etiology and progression of neurodegenerative disorders. RNA modification proteins (RMPs) including FTO, HNRNPA2B1, ADAR1/2, METTL3/14, NSUN2, and ALKBH5 are implicated in initiating dysregulated RNA modifications, thereby disrupting RNA metabolism.
Muhammad Abu Talha Safdar Hashmi +4 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 92, Issue 12, Page 1398-1412, December 2024.ABSTRACT The HIV‐1 protease is critical for the process of viral maturation and as such, it is one of the most well characterized proteins in the Protein Data Bank. There is some evidence to suggest that the HIV‐1 protease is capable of accommodating small molecule fragments at several locations on its surface outside of the active site.
Dean Sherry, Yasien Sayed
wiley +1 more source
Cell Proliferation, Volume 57, Issue 8, August 2024.Aurora kinase A (AURKA) is a crucial protein that controls cell growth and division. It plays a major role in cancer development and progression, causing abnormal cell behaviour. AURKA is often overexpressed in hepatocellular carcinoma (HCC), making it a potential diagnostic and prognostic marker of disease severity.
Luca Grisetti +4 more
wiley +1 more source
, 2022 Journal of the International AIDS Society, Volume 25, Issue S3, August 2022.
wiley +1 more source