Results 71 to 80 of about 1,267 (159)

Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies [PDF]

, 2016
Nanjie Deng, Ashley C. Hoyte, Yara E. Mansour, Mosaad S. Mohamed, James R. Fuchs, Alan Engelman, Mamuka Kvaratskhelia, Ronald M. Levy   +7 more
openalex   +1 more source

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

, 2016
Lei Feng, Venkatasubramanian Dharmarajan, Erik Serrao, Ashley C. Hoyte, Ross C. Larue, Alison Slaughter, Amit Sharma, Matthew Plumb, Jacques J. Kessl, James R. Fuchs, Frederic D. Bushman, Alan Engelman, Patrick R. Griffin, Mamuka Kvaratskhelia   +13 more
openalex   +1 more source

A unique conformational escape reaction of HIV-1 against an allosteric integrase inhibitor [PDF]

, 2019
Tomofumi Nakamura, Teruya Nakamura, Masayuki Amano, Toshikazu Miyakawa, Yuriko Yamagata, Masao Matsuoka, Hirotomo Nakata   +6 more
openalex   +1 more source

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors

, 2019
Francesca Esposito, Mario Sechi, Nicolino Pala, Adele Sanna, Pratibha C. Koneru, Mamuka Kvaratskhelia, Lieve Naesens, Angela Corona, Nicole Grandi, Roberto Di Santo, Vincenzo Maria D’Amore, Francesco Saverio Di Leva, Ettore Novellino, Sandro Cosconati, Enzo Tramontano   +14 more
openalex   +2 more sources

Retrointegration2023-Papers from the 7th International Conference on Retroviral Integration. [PDF]

Viruses
Engelman AN, Grandgenett DP, Maertens GN, Yoder KE, Kvaratskhelia M.   +4 more
europepmc   +1 more source

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity. [PDF]

Molecules, 2023
Tocco G, Canton S, Laus A, Caboni P, Le Grice SFJ, Tramontano E, Esposito F.   +6 more
europepmc   +1 more source

A Substituted Indole Scaffold as a Class of Allosteric HIV-1 Integrase Inhibitor

, 2019
Ross H. Bockbrader
openalex   +1 more source

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain [PDF]

, 2016
Disha Patel, Janet Antwi, Pratibha C. Koneru, Erik Serrao, Stefano Forli, Jacques J. Kessl, Lei Feng, Nanjie Deng, Ronald M. Levy, James R. Fuchs, Arthur J. Olson, Alan Engelman, Joseph D. Bauman, Mamuka Kvaratskhelia, Eddy Arnold   +14 more
openalex   +1 more source

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs

, 2022
B. Narasimhulu Naidu, Manoj Patel, Brian McAuliffe, Bo Ding, Christopher Cianci, Jean Simmermacher, Susan Jenkins, Dawn D. Parker, Prasanna Sivaprakasam, Javed Khan, Kevin Kish, H.A. Lewis, Umesh Hanumegowda, Mark Krystal, Nicholas A. Meanwell, John F. Kadow   +15 more
openalex   +1 more source

Maturation inhibitors: a lost cause? [PDF]

EClinicalMedicine
Pozniak A.
europepmc   +1 more source