Results 101 to 110 of about 19,917 (239)
Regulation of Rat‐Liver Nucleotidase Activity Involving Deoxyribonucleic‐Acid Components as Allosteric Effectors [PDF]
, 1972 Per Fritzson
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Staphylococcus Aureus AgrA Modulators from South African Antimicrobial Plants.
Chemistry &Biodiversity, Accepted Article.South African plants are an underutilized metabolites source for novel antimicrobials targeting key quorum sensing (QS) systems like the Staphylococcus aureus AgrA. AgrA modulating metabolites constitute a new approach to reducing resistance development.
Christiana Eleojo Aruwa, Saheed Sabiu
wiley +1 more source
Molecular Informatics, Volume 41, Issue 12, December 2022., 2022 Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco +2 more
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MoleculesBromodomain-containing protein 9 (BRD9) is a key player in chromatin remodeling and gene expression regulation, and it is closely associated with the development of various diseases, including cancers.
Bin Wang +5 more
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ChemBioChem, EarlyView.Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
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Allosteric Regulation by a Critical Membrane [PDF]
arXiv, 2016 Many of the processes that underly neural computation are carried out by ion channels embedded in the plasma membrane, a two-dimensional liquid that surrounds all cells. Recent experiments have demonstrated that this membrane is poised close to a liquid-liquid critical point in the Ising universality class.
arxiv
Crystal structure of deoxygenated limulus polyphemus subunit II hemocyanin at 2.18 Å resolution: Clues for a mechanism for allosteric regulation [PDF]
, 1993 Bart Hazes +6 more
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Designing Enzymatic Reactivity with an Expanded Palette
ChemBioChem, EarlyView.Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
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ChemBioChem, EarlyView.FtsZ is the only target protein that has been biochemically confirmed to be hydrolyzed both in vitro and in bacterial cells. Coupled with activity‐based protein profiling of nonribosomal peptide synthetases, the ClpP‐ADEP1 proteolytic complex that degrades the surfactin synthetases SrfAA and SrfAB in cell lysates and bacterial cells is demonstrated ...
Fumihiro Ishikawa +4 more
wiley +1 more source
Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach.
PLoS ONE, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of them are highly toxic and ...
Lilian Hernández Alvarez +3 more
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