Results 101 to 110 of about 127,473 (347)

Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]

, 2018
GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Sensing the allosteric force

Nature Communications, 2020
Allosteric regulation is an innate control in most metabolic and signalling cascades that enables living organisms to adapt to the changing environment by tuning the affinity and regulating the activity of target proteins. For a microscopic understanding
Olga Bozovic, Brankica Jankovic, Peter Hamm   +2 more
doaj   +1 more source

Allosteric Regulation of E-Cadherin Adhesion [PDF]

Journal of Biological Chemistry, 2015
Cadherins are transmembrane adhesion proteins that maintain intercellular cohesion in all tissues, and their rapid regulation is essential for organized tissue remodeling. Despite some evidence that cadherin adhesion might be allosterically regulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding affinity
Martha Spano, Barry M. Gumbiner, Nitesh Shashikanth, Jillian Chekan, Taekjip Ha, Stephanie L. Maiden, Deborah E. Leckband, Seongjin Park, Yuliya I. Petrova   +8 more
openaire   +3 more sources

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries. [PDF]

, 2012
The transverse tubular system of rabbit ventricular myocytes consists of cell membrane invaginations (t-tubules) that are essential for efficient cardiac excitation-contraction coupling. In this study, we investigate how t-tubule micro-anatomy, L-type Ca(
Andrew D McCulloch, Anushka Plamenova Michailova, Frank B Sachse, Frank B Sachse, J Andrew eMcCammon, Johan E Hake, Johan E Hake, John H Bridge, Michael J Holst, Peter M Kekenes-Huskey, Yuhui eCheng   +10 more
core   +2 more sources

Allosteric Regulation by Components of a Critical Membrane [PDF]

Biophysical Journal, 2014
We present a simple model of a membrane bound protein allosterically regulated by the local lipid composition. We are motivated by the experimental finding that the plasma membranes of mammalian cells are tuned close to a liquid-liquid critical point, where the sensitivity of many properties to perturbations is large.
openaire   +2 more sources

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

Protein Secondary Structure Patterns in Short‐Range Cross‐Link Atlas

Angewandte Chemie, EarlyView.
Short‐range cross‐linking mass spectrometry (XL‐MS) reveals secondary structure‐dependent patterns in proteome‐wide datasets. By integrating XL‐MS data with AlphaFold‐predicted structures, we introduce X‐SPAN, a novel validation metric that assesses data quality and enables pLDDT score benchmarking.
Alice Vetrano, Alessio Di Ianni, Nico Di Fonte, Gianluca Dell'Orletta, Samantha Reale, Isabella Daidone, Claudio Iacobucci   +6 more
wiley   +2 more sources

The structural basis of ATP as an allosteric modulator.

PLoS Computational Biology, 2014
Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency and protein modification. Recent findings uncovered the allosteric function of ATP in cellular signal transduction but little is understood about this critical ...
Shaoyong Lu, Wenkang Huang, Qi Wang, Qiancheng Shen, Shuai Li, Ruth Nussinov, Jian Zhang   +6 more
doaj   +1 more source