Results 111 to 120 of about 67,162 (289)

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector [PDF]

, 2005
S. Hani Najafi‐Shoushtari, Michael Famulok   +1 more
openalex   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Mutational Insight into Allosteric Regulation of Kir Channel Activity

, 2022
Maryam Yekefallah, Carver A. Rasberry, Evan J. van Aalst, Holley P. Browning, Reza Amani, Derek B. Versteeg, Benjamin J. Wylie   +6 more
openalex   +1 more source

Allosteric Regulation of SecA [PDF]

Journal of Biological Chemistry, 2007
Vicki A.M. Gold, Alice Robson, Anthony R. Clarke, Ian Collinson   +3 more
openaire   +1 more source

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

Nanozyme Microrobots: Programmable Spatiotemporal Catalysis for Targeted Therapy and Diagnostics

Advanced Science, EarlyView.
This review presents nanozyme microrobots as emerging catalytic systems that integrate mobility, external actuation, and adaptive reactivity to achieve precise biochemical functions. By examining mobility‐regulated catalysis, spatial targeting, integrated designs, and translational demonstrations, the article highlights how nanozyme robotics enables ...
Hong Huy Tran, Nil Kanatha Pandey, David P. Cormode, Daeyeon Lee, Edward Steager, Hyun Koo   +5 more
wiley   +1 more source

Multiple allostery in the regulation of PDGFR beta kinase activities

Acta Biochimica et Biophysica Sinica
Platelet-derived growth factor receptor beta (PDGFRβ), a type III receptor tyrosine kinase (RTK) with a featured kinase insert, regulates important cellular functions. Dysregulation of PDGFRβ is associated with cardiovascular and fibrosis diseases. Thus,
Zhang Yanfeng, Wang Meimei, Shao Guangcan, Shang Qingbin, Dong Mengqiu, Qin Xiaohong, Mi Li-Zhi   +6 more
doaj   +1 more source