Results 131 to 140 of about 63,430 (242)

The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts

Cytoskeleton, EarlyView.
ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena, Xiao Zhou, Lauren Slevin, Christopher Brownlee, Rebecca Heald   +4 more
wiley   +1 more source

Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family. [PDF]

Nat Commun, 2023
Deshmukh FK, Ben-Nissan G, Olshina MA, Füzesi-Levi MG, Polkinghorn C, Arkind G, Leushkin Y, Fainer I, Fleishman SJ, Tawfik D, Sharon M.   +10 more
europepmc   +1 more source

The S subunit of d-ornithine aminomutase fromClostridium sticklandiiis responsible for the allosteric regulation in d-α-lysine aminomutase [PDF]

, 2007
Cheng-Hsing Tseng, Cheng-His Yang, Heng‐Ju Lin, Chun‐Hung Wu, Hao‐Ping Chen   +4 more
openalex   +1 more source

Dissecting the Structural Organization, Recruitment and Activation Mechanisms of Centrosomal γ‐TuRCs

Cytoskeleton, EarlyView.
ABSTRACT Visualizing human centrosomes using cryo‐electron tomography revealed the native structure and molecular organization of γ‐tubulin ring complexes (γ‐TuRCs). γ‐TuRCs localized to two distinct centrosomal pools, one in the pericentriolar material (PCM) and another in the centriole lumen, which is released during mitosis.
Florian W. Hofer, Martin Würtz, Qi Gao, Bram J. A. Vermeulen, Elmar Schiebel, Stefan Pfeffer   +5 more
wiley   +1 more source

Intradomain Allosteric Regulation of Soluble Epoxide Hydrolase by Its Substrates. [PDF]

Int J Mol Sci
Matsumura S, Shida A, Tsuchii M, Wada M, Charneau J, Tsuji M, Hasumi K, Suzuki E.   +7 more
europepmc   +1 more source

Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. [PDF]

J Biol Chem, 2023
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM.   +10 more
europepmc   +1 more source

Potent, Selective, and Drug‐like G Protein‐coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X‐ray Structural Studies

ChemMedChem, Accepted Article.
We report here the design, synthesis, and evaluation of small molecules, drug‐like G protein‐coupled receptor kinase 5 (GRK5) inhibitors. GRK5 has become an important drug development target against heart failure and cancer. GRK6, a close homolog of GRK5, is considered as a possible therapeutic target for multiple myeloma.
Arun K Ghosh, Ranjith Kumar Gadi, Yueyi Chen, Sandali Piladuwa Gamage, Kathryn McCauley, John J. G. Tesmer   +5 more
wiley   +1 more source

Conformational Remodeling and Allosteric Regulation Underlying EGFR Mutant-Induced Activation: A Multi-Scale Analysis Using MD, MSMs, and NRI. [PDF]

Int J Mol Sci
Duan H, Zhao DR, Liu MT, Yang LQ, Sang P.   +4 more
europepmc   +1 more source

Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. [PDF]

Protein Cell, 2023
Liu L, Wang P, Liu A, Zhang L, Yan L, Guo Y, Xiao G, Rao Z, Lou Z.   +8 more
europepmc   +1 more source

Allosteric Regulation of Bacillus subtilis NAD Kinase by Quinolinic Acid

, 2003
Silvia Garavaglia, Alessandro Galizzi, Menico Rizzi   +2 more
openalex   +1 more source