Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector [PDF]
, 2005 S. Hani Najafi‐Shoushtari +1 more
openalex +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, EarlyView.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
High-gain nonlinear observer for simple genetic regulation process
, 2007 High-gain nonlinear observers occur in the nonlinear automatic control theory and are in standard usage in chemical engineering processes. We apply such a type of analysis in the context of a very simple one-gene regulation circuit.
Barkai +19 more
core +2 more sources
ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks [PDF]
, 2015 Qiancheng Shen +12 more
openalex +1 more source
Mutational Insight into Allosteric Regulation of Kir Channel Activity
, 2022 Maryam Yekefallah +6 more
openalex +1 more source
Zuranolone: A case study in (regulatory) rush to judgement?
British Journal of Clinical Pharmacology, EarlyView.Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
wiley +1 more source
Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema. [PDF]
, 2007 Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema.
Chris J. Armit +6 more
core +1 more source
GLP‐1 agonists and the gut microbiome: A bidirectional relationship
British Journal of Clinical Pharmacology, EarlyView.Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath +2 more
wiley +1 more source
Allosteric Regulation of the Follicle-Stimulating Hormone Receptor [PDF]
, 2018 Selvaraj Nataraja +2 more
openalex +1 more source
Allosteric Regulation of SecA [PDF]
Journal of Biological Chemistry, 2007 Vicki A.M. Gold +3 more
openaire +1 more source