Results 141 to 150 of about 63,430 (242)

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder

Clinical Pharmacology &Therapeutics, EarlyView.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre, Gerard Sanacora, David P. Walling, Elan A. Cohen, Shishuka Malhotra, Holger Rosenbrock, Manuela Schmitz, Andreas Scholz, Sigurd D. Süssmuth, Franco De Crescenzo   +9 more
wiley   +1 more source

Deciphering the allosteric regulation of mycobacterial inosine-5'-monophosphate dehydrogenase. [PDF]

Nat Commun
Bulvas O, Knejzlík Z, Sýs J, Filimoněnko A, Čížková M, Clarová K, Rejman D, Kouba T, Pichová I.   +8 more
europepmc   +1 more source

Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands [PDF]

, 2009
Christopher N. Davis, Stefania Risso Bradley, Hans H. Schiffer, Mikael Friberg, Kristian Koch, Bo‐Ragnar Tolf, Douglas W. Bonhaus, Jelveh Lameh   +7 more
openalex   +1 more source

Allosteric regulation in drug design [PDF]

Current Trends in Biomedical Engineering & Biosciences, 2017
openaire   +2 more sources

Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3‐Way Crossover Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is approved as an adjunctive treatment of seizures associated with Dravet syndrome, Lennox–Gastaut Syndrome, and tuberous sclerosis. Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti‐seizure medication (ASM).
Andriy A. Gorbenko, Catherine M.K.E. de Cuba, Annika A. de Goede, Titiaan E. Post, Roman Bohoslavsky, Pamela K. Strugala, Jules A.A.C. Heuberger, Geert Jan Groeneveld   +7 more
wiley   +1 more source

Structural basis for allosteric regulation of human phosphofructokinase-1. [PDF]

Nat Commun
Lynch EM, Hansen H, Salay L, Cooper M, Timr S, Kollman JM, Webb BA.   +6 more
europepmc   +1 more source

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase. [PDF]

Viruses, 2022
Masuda T, Kotani O, Yokoyama M, Abe Y, Kawai G, Sato H.   +5 more
europepmc   +1 more source

Kinetic Evidence for Interdomain Communication in the Allosteric Regulation of α-Isopropylmalate Synthase from Mycobacterium tuberculosis [PDF]

, 2009
Luiz Pedro S. de Carvalho, Patrick A. Frantom, Argyrides Argyrou, John S. Blanchard   +3 more
openalex   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

A short intrinsically disordered region at KtrB's N-terminus facilitates allosteric regulation of K⁺ channel KtrAB. [PDF]

Nat Commun
Stautz J, Griwatz D, Kaltwasser S, Mehdipour AR, Ketter S, Thiel C, Wunnicke D, Schrecker M, Mills DJ, Hummer G, Vonck J, Hänelt I.   +11 more
europepmc   +1 more source