Oncology Dose Optimization: Tailored Approaches to Different Molecular Classes
Clinical Pharmacology &Therapeutics, EarlyView.Oncology dose optimization during the era of chemotherapy focused on identifying the maximum tolerated dose (MTD) for registrational trials, often resulting in significant toxicity. The advent of molecular targeted drugs and immunotherapies offers the potential to achieve similar efficacy with lower doses and fewer side effects, as maximal efficacy is ...
Jiawen Zhu +12 more
wiley +1 more source
Crystallographic studies of ribonucleotide reductase fromSalmonella typhimurium. Clues about the allosteric regulation [PDF]
, 2002 Malin Uppsten +3 more
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Grape Stalks Valorization towards Circular Economy: A Cascade Biorefinery Strategy
ChemSusChem, EarlyView.A cascade protocol for grape stalks valorization has been proposed, characterized by a multidisciplinary strategy using unconventional techniques and subcritical water as a green solvent, where physical/chemical treatments synergistically interact with biological treatments to obtain added value products from all the biomass components.
Carlotta Valle +11 more
wiley +1 more source
Allosteric regulation of the access channels to the Rb+ occlusion sites of (Na+ + K+)-ATPase.
, 1993 Jan Hasenauer, W.H. Huang, Amir Askari
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Differential regulation of nitric oxide synthases and their allosteric regulators in heart and vessels of hypertensive rats [PDF]
, 2003 Alina Piech +4 more
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Drug Testing and Analysis, EarlyView.Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer +13 more
wiley +1 more source
Structure and allosteric regulation of the αXβ2 integrin I domain [PDF]
, 2003 Thomas Vorup‐Jensen +4 more
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The link of FOXO1 and FOXO4 transcription factors to development of the lens
Developmental Dynamics, EarlyView.Abstract Background The FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens.
Rifah N. Gheyas +3 more
wiley +1 more source
Identification of Regions of the Tomato γ-Glutamyl Kinase That Are Involved in Allosteric Regulation by Proline [PDF]
, 2003 Tomomichi Fujita +5 more
openalex +1 more source