Results 151 to 160 of about 130,849 (328)
Advanced Science, EarlyView.This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu +4 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang +3 more
wiley +1 more source
Allosteric Regulation of SecA [PDF]
Journal of Biological Chemistry, 2007 Vicki A.M. Gold +3 more
openaire +1 more source
Targeted Medical Therapies for Vascular Anomalies: A Clinical Review
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Vascular anomalies represent a broad spectrum of disorders characterized by aberrant blood or lymphatic vessel development, which can lead to complex clinical phenotypes. Historically, vascular anomalies were classified solely on the basis of their clinical and histopathologic features.
Whitney Eng
wiley +1 more source
Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides [PDF]
, 2015 Hannah A. DeBerg +4 more
openalex +1 more source
Molecular Requirements for Ethanol Differential Allosteric Modulation of Ligand-Gated Ion Channels Based on Selective G Beta Gamma Modulation [PDF]
, 2010 It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure.
Aguayo, Luis G +6 more
core +1 more source
Multiple allostery in the regulation of PDGFR beta kinase activities
Acta Biochimica et Biophysica SinicaPlatelet-derived growth factor receptor beta (PDGFRβ), a type III receptor tyrosine kinase (RTK) with a featured kinase insert, regulates important cellular functions. Dysregulation of PDGFRβ is associated with cardiovascular and fibrosis diseases. Thus,
Zhang Yanfeng +6 more
doaj +1 more source
Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector [PDF]
, 2005 S. Hani Najafi‐Shoushtari +1 more
openalex +1 more source
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation
Angewandte Chemie International Edition, EarlyView.Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer +11 more
wiley +1 more source