Results 161 to 170 of about 67,162 (289)

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. [PDF]

Nat Commun
Nguyen BV, Özden C, Dong K, Koc OC, Torres-Ocampo AP, Dziedzic N, Flaherty D, Huang J, Sankara S, Abromson NL, Tomchick DR, Fissore RA, Chen J, Garman SC, Stratton MM.   +14 more
europepmc   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism. [PDF]

Nat Commun
Maillet L, Fétiveau A, Lalier L, Martin N, Barillé-Nion S, Guette C, Gautier F, Téletchéa S, Juin PP.   +8 more
europepmc   +1 more source

Allosteric regulation and inhibition of protein kinases. [PDF]

Biochem Soc Trans, 2023
Mingione VR, Paung Y, Outhwaite IR, Seeliger MA.   +3 more
europepmc   +1 more source

Abstract 2732: Allosteric regulation of thioesterase superfamily member 1 by a lipid sensor domain binding fatty acids and lysophosphatidylcholine

, 2023
Eric A. Ortlund
openalex   +1 more source

Olive‐derived bioactive combinations: synergistic angiotensin‐I‐converting enzyme (ACE) inhibition and distinct mechanisms of triterpenic acids and phenolics

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Cardiovascular diseases, largely driven by hypertension, remain the leading cause of mortality worldwide. Angiotensin‐I‐converting enzyme (ACE) inhibition is a well‐established therapeutic approach; however, synthetic inhibitors are frequently associated with adverse effects.
Fátima Rubio‐Senent, Alejandra Bermúdez‐Oria, África Fernández‐Prior, Antonio Lama‐Muñoz, Guillermo Rodríguez‐Gutiérrez, Juan Fernández‐Bolaños   +5 more
wiley   +1 more source

Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson's disease. [PDF]

J Biol Chem
Adhikari A, Tripathi A, Chiang CY, Sherpa P, Pfeffer SR.   +4 more
europepmc   +1 more source

Identification of a Target Site in Plasminogen Activator Inhibitor-1 That Allows Neutralization of Its Inhibitory Properties Concomitant with an Allosteric Up-regulation of Its Antiadhesive Properties [PDF]

, 2001
Thu-Hoa Ngo, Marc Hoylaerts, Isabelle Knockaert, Els Brouwers, Paul Declerck   +4 more
openalex   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Allosteric regulation of proteolytic machines unveiled by the synergy between cryo-EM and solution NMR spectroscopy. [PDF]

Biochem J
Turner M, Harkness RW, Ripstein ZA, Huang R, Vahidi S.   +4 more
europepmc   +1 more source