Results 161 to 170 of about 130,849 (328)

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR

Nature Communications
The M5 muscarinic acetylcholine receptor (M5 mAChR) represents a promising therapeutic target for neurological disorders. However, the high conservation of its orthosteric binding site poses significant challenges for drug development.
Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal   +13 more
doaj   +1 more source

Author Correction: Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism [PDF]

, 2023
Zachary Maben, Richa Arya, Dimitris Georgiadis, Efstratios Stratikos, Lawrence J. Stern   +4 more
openalex   +1 more source

Investigation of allosteric regulation of porcine fructose-1,6-bisphosphatase

, 2007
Jian Lü
openalex   +2 more sources

Structural basis for the allosteric regulation of the SbtA bicarbonate transporter by the P_II-like protein, SbtB, fromCyanobiumsp. PCC7001

, 2019
Joe A. Kaczmarski, Nansook Hong, Bratati Mukherjee, Laura T. Wey, Loraine M. Rourke, Britta Förster, Thomas S. Peat, G. Dean Price, Colin J. Jackson   +8 more
openalex   +1 more source

Allosteric regulation of glycerol kinase by enzyme IIIglc of the phosphotransferase system in Escherichia coli and Salmonella typhimurium [PDF]

, 1985
Maria Novotny, Willard L. Frederickson, E. Bruce Waygood, Milton H. Saier   +3 more
openalex   +1 more source

Biochemistry Learning in Higher Education: A Systematic Review on Methodologies and Teaching Resources

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT The teaching of biochemistry in higher education presents several challenges, including the complexity of molecular visualization, the use of technical terminology, and the vast amount of content covered in courses. This systematic review explores current research on biochemistry teaching at the higher education level published between 2012 ...
Micaela Jardim e Silva, Mariana Silva Cecilio, Maurícius Selvero Pazinato   +2 more
wiley   +1 more source

Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe₄L₆ Tetrahedron

, 2018
Larissa K. S. von Krbek, Derrick A. Roberts, Ben S. Pilgrim, Christoph A. Schalley, Jonathan R. Nitschke   +4 more
openalex   +2 more sources

eLife Assessment: Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

, 2023
Volker Dötsch
openalex   +1 more source

eLife Assessment: Allosteric regulation of kinase activity in living cells [PDF]

, 2023
Volker Dötsch
openalex   +1 more source

Periodontitis treatment and microbiome in a patient with FAM20A mutation: Case study of 1.5 years

Clinical Advances in Periodontics, EarlyView.
Abstract Background Enamel‐renal‐gingival syndrome (ERGS) is an autosomal recessive disorder caused by mutations in the FAMily with sequence similarity 20A (FAM20A) gene, and is characterized by amelogenesis imperfecta, delayed or failed tooth eruption, and periodontitis.
John Rong Hao Tay, Preethi Balan, Chaminda Jayampath Seneviratne   +2 more
wiley   +1 more source