Results 161 to 170 of about 63,430 (242)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Structural basis of the allosteric regulation of cyanobacterial glucose-6-phosphate dehydrogenase by the redox sensor OpcA. [PDF]

Proc Natl Acad Sci U S A
Doello S, Shvarev D, Theune M, Sauerwein J, Klon A, Keskin E, Boehm M, Gutekunst K, Forchhammer K.   +8 more
europepmc   +1 more source

Allosteric regulation of autoinhibition and activation of c-Abl. [PDF]

Comput Struct Biotechnol J, 2022
Liu Y, Zhang M, Tsai CJ, Jang H, Nussinov R.   +4 more
europepmc   +1 more source

Elastic network model of allosteric regulation in protein kinase PDK1 [PDF]

, 2010
Gareth Williams
openalex   +1 more source

Autophagy‐Targeting Nanomedicine: Strike at the Heart of the Cancer via Precise Modulation of Autophagy

Exploration, EarlyView.
This review emphasizes the critical role of autophagy in cancer treatment, highlighting the development of autophagy‐targeting nanomedicines and their applications in combination therapies. It explores how nanoplatforms can effectively regulate autophagy, underscoring the potential of integrating autophagy modulation with other treatment strategies to ...
Zhouyi Sun, Huali Zuo, Kai Zhang, Yang Liu, Qianwen Wang, Qitao Hu, Jiwei Qian, Andreas Lundqvist, Bo Zhang, Weiyu Chen, Zhe Tang   +10 more
wiley   +1 more source

What is allosteric regulation? Exploring the exceptions that prove the rule! [PDF]

J Biol Chem
McCullagh M, Zeczycki TN, Kariyawasam CS, Durie CL, Halkidis K, Fitzkee NC, Holt JM, Fenton AW.   +7 more
europepmc   +1 more source

The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases. [PDF]

Protein Sci, 2022
Buey RM, Fernández-Justel D, Jiménez A, Revuelta JL.   +3 more
europepmc   +1 more source

Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

, 2006
Fiona E. Baird, Jorge J. Pinilla-Tenas, William L. J. Ogilvie, Vadival Ganapathy, Harinder S. Hundal, Peter M. Taylor   +5 more
openalex   +2 more sources

Engineering allosteric regulation into the hinge region of a circularly permuted TEM-1 β-lactamase [PDF]

, 2010
Valéry Mathieu, Jacques Fastrez, Patrice Soumillion   +2 more
openalex   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source