Results 161 to 170 of about 127,473 (347)

Allosteric Regulation of Catalytic Activity: Escherichia coli Aspartate Transcarbamoylase versus Yeast Chorismate Mutase [PDF]

, 2001
Kerstin Helmstaedt, Sven Krappmann, Gerhard H. Braus   +2 more
openalex   +1 more source

Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization

ChemMedChem, EarlyView.
A multitier computational strategy discovers potential USP7 inhibitors using similarity‐based virtual screening, physics‐driven molecular simulations, binding free energy estimations, binary QSAR modeling, and steered molecular dynamics analysis. This integrated approach prioritizes and optimizes lead compounds with strong predicted affinity, offering ...
Ehsan Sayyah, Muhammet Eren Ulug, Serdar Durdağı   +2 more
wiley   +1 more source

Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors

ChemPlusChem, EarlyView.
A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou, Nikitas Georgiou, Demeter Tzeli, Nikolaos Karousis, George Varvounis   +4 more
wiley   +1 more source

Disorder driven allosteric control of protein activity

Current Research in Structural Biology, 2020
Studies of protein allostery increasingly reveal an involvement of the back and forth order-disorder transitions in this mechanism of protein activity regulation.
Wei-Ven Tee, Enrico Guarnera, Igor N. Berezovsky   +2 more
doaj  

Allosteric transitions of phosphorylase a and the regulation of glycogen metabolism.

, 1978
Neil B. Madsen, Peter J. Kasvinsky, Robert J. Fletterick   +2 more
openalex   +1 more source

The gdhB Gene of Pseudomonas aeruginosa Encodes an Arginine-Inducible NAD ⁺ -Dependent Glutamate Dehydrogenase Which Is Subject to Allosteric Regulation [PDF]

, 2001
Chung‐Dar Lu, Ahmed T. Abdelal
openalex   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

Allosteric regulation of the state of adenylylation of glutamine synthetase in permeabilized cell preparations of Escherichia coli. Studies of monocyclic and bicyclic interconvertible enzyme cascades, in situ.

, 1981
Umberto Mura, P Boon Chock, Earl R. Stadtman   +2 more
openalex   +1 more source

Structural basis for allosteric substrate specificity regulation in anaerobic ribonucleotide reductases [PDF]

, 2002
Derek T. Logan, Karl-Magnus Larsson, Britt Marie Sjoeberg, P. Nordlund   +3 more
openalex   +1 more source

The link of FOXO1 and FOXO4 transcription factors to development of the lens

Developmental Dynamics, EarlyView.
Abstract Background The FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens.
Rifah N. Gheyas, Ruby C. Williams, Kelly A. Ryan, A. Sue Menko   +3 more
wiley   +1 more source