Results 181 to 190 of about 130,849 (328)

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Allosteric regulation of prostaglandin endoperoxide H₂ synthases. [PDF]

J Biol Chem
Dong L, Malkowski MG.
europepmc   +1 more source

Emerging maps of allosteric regulation in cellular networks. [PDF]

Curr Opin Struct Biol, 2023
Mathy CJP, Kortemme T.
europepmc   +1 more source

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction [PDF]

, 2019
Brent W. Anderson, Kuanqing Liu, Christine Wolak, Katarzyna Dubiel, Kenneth A. Satyshur, James L. Keck, Jue D. Wang   +6 more
openalex   +1 more source

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

, 2021
Grace France, Rasa Volianskis, Rachael Ingram, Neil Bannister, R. Rothärmel, Mark W. Irvine, G. Fang, Erica S. Burnell, Kiran Sapkota, Blaise M. Costa, Divija Chopra, Shashank M. Dravid, Adina T. Michael‐Titus, Daniel T. Monaghan, John Georgiou, Zuner A. Bortolotto, David E. Jane, Graham L. Collingridge, Arturas Volianskis   +18 more
openalex   +1 more source

Computational modelling of myocardial metabolism in patients with advanced heart failure

European Journal of Heart Failure, EarlyView.
LV, left ventricular; LVAD, left ventricular assist device; LVEF, left ventricular ejection fraction. Abstract Aims Perturbations of myocardial metabolism and energy depletion are well‐established hallmarks of heart failure (HF), yet methods for their systematic assessment remain limited in humans.
Niklas Beyhoff, Vera M. Braun, Marieluise Kirchner, Lucy E.M. Finnigan, Christoph Knosalla, István Baczkó, Evgenij Potapov, Ulrich Kintscher, Tilman Grune, Titus Kuehne, Hermann‐Georg Holzhütter, Philipp Mertins, Damian J. Tyler, Hendrik Milting, Betty Raman, Oliver J. Rider, Stefan Neubauer, Nikolaus Berndt   +17 more
wiley   +1 more source

Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex. [PDF]

Nat Commun
Giladi M, Kredi S, Guardiani C, Aviram L, Vaňková P, Gaizinger Y, Man P, Giacomello A, Haitin Y.   +8 more
europepmc   +1 more source

Spotlight commentary: Addressing the persistent problem of benzodiazepine overuse, time for clinical, educational and AI‐driven reform

British Journal of Clinical Pharmacology, EarlyView.
Jakša Vukojević, Luka Horvat, Vito Papić, Andrija Štajduhar   +3 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

A dynamic structural framework for the allosteric regulation of Hsp70 chaperones. [PDF]

J Biol Chem
Rohland L, Kityk R, Smalinskaitė-Wolf L, Lashkul V, Mayer MP.   +4 more
europepmc   +1 more source