Results 211 to 220 of about 68,403 (252)

A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling. [PDF]

Nat Chem Biol
Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P.   +7 more
europepmc   +1 more source

Allosteric regulation of nitrate transporter NRT via the signaling protein PII. [PDF]

Proc Natl Acad Sci U S A
Li B, Wang XQ, Li QY, Xu D, Li J, Hou WT, Chen Y, Jiang YL, Zhou CZ.   +8 more
europepmc   +1 more source

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Allosteric Regulation of Proteases

ChemBioChem, 2008
AbstractAllostery is a basic principle of control of enzymatic activities based on the interaction of a protein or small molecule at a site distinct from an enzyme's active center. Allosteric modulators represent an alternative approach to the design and synthesis of small‐molecule activators or inhibitors of proteases and are therefore of wide ...
Patrick Hauske, Michael Meltzer, Michael Ehrmann   +2 more
exaly   +4 more sources

Ribonucleotide Reductases: The Evolution of Allosteric Regulation

Archives of Biochemistry and Biophysics, 2002
Ribonucleotide reductases catalyze in all living organisms the production of the deoxyribonucleotides required for DNA replication and repair. Their appearance during evolution was a prerequisite for the transition from the "RNA world," where RNA sufficed for both catalysis and information transfer, to today's situation where life depends on the ...
P Reichard
exaly   +3 more sources

Allosteric regulation, cooperativity, and biochemical oscillations

Biophysical Chemistry, 1990
Allosteric regulation is associated with a number of periodic phenomena in biochemical systems. The cooperative nature of such regulatory interactions provides a source of nonlinearity that favors oscillatory behavior. We assess the role of cooperativity in the onset of biochemical oscillations by analyzing two specific examples.
Albert Goldbeter, Genevieve Dupont, G Dupont   +2 more
exaly   +4 more sources

Allosteric regulation of chaperonins

Current Opinion in Structural Biology, 2005
Chaperonins are molecular machines that facilitate protein folding by undergoing energy (ATP)-dependent movements that are coordinated in time and space by complex allosteric regulation. Recently, progress has been made in describing the various functional (allosteric) states of these machines, the pathways by which they interconvert, and the coupling ...
Horovitz, A, Willison, KR
openaire   +3 more sources

Aptamers for allosteric regulation

Nature Chemical Biology, 2011
Aptamers are useful for allosteric regulation because they are nucleic acid-based structures in which ligand binding induces conformational changes that may alter the function of a connected oligonucleotide at a distant site. Through this approach, a specific input is efficiently converted into an altered output.
Vinkenborg, J., Karnowski, N., Famulok, M.   +2 more
openaire   +3 more sources

Diversity of Allosteric Regulation in Proteases

ACS Chemical Biology, 2012
Allostery is a fundamental regulatory mechanism that is based on a functional modulation of a site by a distant site. Allosteric regulation can be triggered by binding of diverse allosteric effectors, ranging from small molecules to macromolecules, and is therefore offering promising opportunities for functional modulation in a wide range of ...
Merdanovic, Melisa, Mönig, Timon, Ehrmann, Michael, Kaiser, Markus   +3 more
openaire   +3 more sources

Engineered Allosteric Regulation of Protein Function

Journal of Molecular Biology, 2022
Allosteric regulation of proteins has been utilized to study various aspects of cell signaling, from unicellular events to organism-wide phenotypes. However, traditional methods of allosteric regulation, such as constitutively active mutants and inhibitors, lack tight spatiotemporal control.
Jordan, Fauser, Nicholas, Leschinsky, Barbara N, Szynal, Andrei V, Karginov   +3 more
openaire   +2 more sources

The role of dynamics in allosteric regulation

Current Opinion in Structural Biology, 2003
The biomolecular conformational changes often associated with allostery are, by definition, dynamic processes. Recent publications have disclosed the role of pre-existing equilibria of conformational substates in this process. In addition, the role of dynamics as an entropic carrier of free energy of allostery has been investigated.
Dorothee, Kern, Erik R P, Zuiderweg
openaire   +2 more sources