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NADPH Is an Allosteric Regulator of HSCARG
Journal of Molecular Biology, 2009NADP(H) is an important cofactor that controls many fundamental cellular processes. We have determined the crystal structure of HSCARG, a novel NADPH sensor, and found that it forms an asymmetrical dimer with only one subunit occupied by an NADPH molecule, and the two subunits have dramatically different conformations.
Xueyu, Dai +8 more
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Allosteric regulation of phosphoribulokinase activity
Biochemical and Biophysical Research Communications, 1968Inhibition of ATP-dependent CO2 fixation by AMP has been reported in several autotrophic organisms (Johnson and Peck, 1965; Mayeux and Johnson, 1966;Johnson, 1966; Gale and Beck, 1966). Johnson (1966) suggested that the site of AMP inhibition is phosphoribulokinase and that inhibition may occur through allosteric modification of the enzyme. In contrast,
R D, MacElroy +2 more
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Allosteric regulation of crocodilian haemoglobin
Nature, 1981The oxygen affinity of most vertebrate haemoglobins in the absence of diffusible electrolytes is much higher than that of blood. In the red cell this affinity is lowered by organic phosphates, hydrogen ions, chloride ions and CO2 (refs 1–5). Similarly, crocodilian haemoglobin also has a much higher oxygen affinity than crocodile blood, but this is due ...
Perutz, Max M.F. +8 more
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Allosteric regulation of platelet actomyosin
Biochemical and Biophysical Research Communications, 1973Abstract The kinetic properties of platelet actomyosin have been examined to understand the mode of hydrolysis of its substrate ATP. In the presence of divalent cations, ATP hydrolysis deviated from Michaelis-Menten kinetics in such a way as to indicate cooperative effects, with a sigmoidal velocity vs.
M N, Malik, T C, Detwiler, A, Stracher
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Targeting allosteric regulation of cancer metabolism
Nature Chemical Biology, 2022Metabolic reprogramming is observed across all cancer types. Indeed, the success of many classic chemotherapies stems from their targeting of cancer metabolism. Contemporary research in this area has refined our understanding of tumor-specific metabolic mechanisms and has revealed strategies for exploiting these vulnerabilities selectively.
Daniel M. Kremer, Costas A. Lyssiotis
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Allosteric regulation and inhibition of protein kinases
Biochemical Society Transactions, 2023The human genome encodes more than 500 different protein kinases: signaling enzymes with tightly regulated activity. Enzymatic activity within the conserved kinase domain is influenced by numerous regulatory inputs including the binding of regulatory domains, substrates, and the effect of post-translational modifications such as autophosphorylation ...
Victoria R. Mingione +3 more
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Nucleosomes as allosteric scaffolds for genetic regulation
Current Opinion in Structural Biology, 2020Nucleosomes are stable yet highly dynamic complexes exhibiting diverse types of motions, such as sliding, DNA unwrapping, and disassembly, encoding a landscape with a large number of metastable states. In this review, describing recent studies on these nucleosome structure changes, we propose that the nucleosome can be viewed as an ideal allosteric ...
Shoji Takada +2 more
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Allosteric Regulation of Chromatin-Modifying Enzymes
Biochemistry, 2018Dynamic changes in chromatin structure are crucial for diverse biological processes. Given the complexity of the epigenetic landscape, understanding the specificity of chromatin modification has been a major interest in the epigenetics field. Recent progress in biochemical and structural analyses in the field of chromatin biology has revealed that ...
Jung-Ae Kim, Minjung Kwon, Jaehoon Kim
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Allosteric effects of DNA on transcriptional regulators
Nature, 1998Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is ...
J A, Lefstin, K R, Yamamoto
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DNA as an Allosteric Regulator
Science Signaling, 2009The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor.
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