Results 221 to 230 of about 68,671 (251)
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Allosteric regulation of crocodilian haemoglobin
Nature, 1981The oxygen affinity of most vertebrate haemoglobins in the absence of diffusible electrolytes is much higher than that of blood. In the red cell this affinity is lowered by organic phosphates, hydrogen ions, chloride ions and CO2 (refs 1–5). Similarly, crocodilian haemoglobin also has a much higher oxygen affinity than crocodile blood, but this is due ...
Perutz, Max M.F. +8 more
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Allosteric regulation of platelet actomyosin
Biochemical and Biophysical Research Communications, 1973Abstract The kinetic properties of platelet actomyosin have been examined to understand the mode of hydrolysis of its substrate ATP. In the presence of divalent cations, ATP hydrolysis deviated from Michaelis-Menten kinetics in such a way as to indicate cooperative effects, with a sigmoidal velocity vs.
M N, Malik, T C, Detwiler, A, Stracher
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Targeting allosteric regulation of cancer metabolism
Nature Chemical Biology, 2022Metabolic reprogramming is observed across all cancer types. Indeed, the success of many classic chemotherapies stems from their targeting of cancer metabolism. Contemporary research in this area has refined our understanding of tumor-specific metabolic mechanisms and has revealed strategies for exploiting these vulnerabilities selectively.
Daniel M. Kremer, Costas A. Lyssiotis
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Allosteric Regulation of Chromatin-Modifying Enzymes
Biochemistry, 2018Dynamic changes in chromatin structure are crucial for diverse biological processes. Given the complexity of the epigenetic landscape, understanding the specificity of chromatin modification has been a major interest in the epigenetics field. Recent progress in biochemical and structural analyses in the field of chromatin biology has revealed that ...
Jung-Ae Kim, Minjung Kwon, Jaehoon Kim
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Allosteric effects of DNA on transcriptional regulators
Nature, 1998Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is ...
J A, Lefstin, K R, Yamamoto
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Allosteric regulation of Warts
Science Signaling, 2016Hippo pathway regulators allosterically switch the conformation of the kinase Warts.
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DNA as an Allosteric Regulator
Science Signaling, 2009The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor.
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Allosteric regulation, cooperativity, and biochemical oscillations
Biophysical Chemistry, 1990Allosteric regulation is associated with a number of periodic phenomena in biochemical systems. The cooperative nature of such regulatory interactions provides a source of nonlinearity that favors oscillatory behavior. We assess the role of cooperativity in the onset of biochemical oscillations by analyzing two specific examples.
Goldbeter, Albert, Dupont, Geneviève
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An engineered chorismate mutase with allosteric regulation
Bioorganic & Medicinal Chemistry, 2003Besides playing a central role in phenylalanine biosynthesis, the bifunctional P-protein in Eschericia coli provides a unique model system for investigating whether allosteric effects can be engineered into protein catalysts using modular regulatory elements.
Sheng, Zhang +2 more
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The ribosome as an allosterically regulated molecular machine
Biochemistry (Moscow), 2017The ribosome as a complex molecular machine undergoes significant conformational rearrangements during the synthesis of polypeptide chains of proteins. In this review, information obtained using various experimental methods on the internal consistency of such rearrangements is discussed.
T M, Makarova, A A, Bogdanov
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