Results 111 to 120 of about 79,838 (161)

Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors. [PDF]

Nat Commun
Lin YY, Lu Y, Li CY, Ma XF, Shao MQ, Gao YH, Zhang YQ, Jiang HN, Liu Y, Yang Y, Huang LD, Cao P, Wang HS, Wang J, Yu Y.   +14 more
europepmc   +1 more source

Exploring an Intracellular Allosteric Site of CC-Chemokine Receptor 4 from 3D Models, Probe Simulations, and Mutagenesis. [PDF]

ACS Pharmacol Transl Sci
Ding T, Guseinov AA, Milligan G, Plouffe B, Tikhonova IG.   +4 more
europepmc   +1 more source

Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors. [PDF]

Comput Struct Biotechnol J
Omage FB, Salim JA, Mazoni I, Yano IH, Borro L, Gonzalez JEH, de Moraes FR, Giachetto PF, Tasic L, Arni RK, Neshich G.   +10 more
europepmc   +1 more source

Identification of the pyridoxal 5'-phosphate allosteric site in human pyridox(am)ine 5'-phosphate oxidase. [PDF]

Protein Sci
Barile A, Graziani C, Antonelli L, Parroni A, Fiorillo A, di Salvo ML, Ilari A, Giorgi A, Rosignoli S, Paiardini A, Contestabile R, Tramonti A.   +11 more
europepmc   +1 more source

An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. [PDF]

Sci Signal, 2020
Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM.   +16 more
europepmc   +1 more source

Correction: Suriya et al. Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-Activated Protein Kinase (MAPK) at the Allosteric Site. <i>Pharmaceutics</i> 2022, <i>14</i>, 1461. [PDF]

Pharmaceutics
Suriya U, Mahalapbutr P, Rungrotmongkol T.   +2 more
europepmc   +1 more source

Targeting Allosteric Site of PCSK9 Enzyme for the Identification of Small Molecule Inhibitors: An In Silico Drug Repurposing Study. [PDF]

Biomedicines
Charbe NB, Zacconi FC, Kowthavarapu VK, Gupta C, Palakurthi SS, Satheeshkumar R, Lokwani DK, Tambuwala MM, Palakurthi S.   +8 more
europepmc   +1 more source

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Multiple allosteric sites on muscarinic receptors

Life Sciences, 2001
Proteins and small molecules are capable of regulating the agonist binding and function of G-protein coupled receptors by multiple allosteric mechanisms. In the case of muscarinic receptors, there is the well-characterised allosteric site that binds, for example, gallamine and brucine. The protein kinase inhibitor, KT5720, has now been shown to bind to
N J, Birdsall, S, Lazareno, A, Popham, J, Saldanha   +3 more
openaire   +2 more sources

Uncovering the Dominant Motion Modes of Allosteric Regulation Improves Allosteric Site Prediction

Journal of Chemical Information and Modeling, 2021
Allostery is an important mechanism that biological systems use to regulate function at a distant site. Allosteric drugs have attracted much attention in recent years due to their high specificity and the possibility of overcoming existing drug-resistant mutations.
Juan Xie, Shiwei Wang, Youjun Xu, Minghua Deng, Luhua Lai   +4 more
openaire   +2 more sources

Crosslinking Allosteric Sites on the Nucleosome

Angewandte Chemie International Edition, 2019
AbstractTargeting defined histone protein sites in chromatin is an emerging therapeutic approach that can potentially be enhanced by allosteric effects within the nucleosome. Here we characterized a novel hetero‐bimetallic compound with a design based on a nucleosomal allostery effect observed earlier for two unrelated drugs—the RuII antimetastasis ...
Lucinda K. Batchelor, Louis De Falco, Thibaud von Erlach, Deepti Sharma, Zenita Adhireksan, Ursula Roethlisberger, Curt A. Davey, Paul J. Dyson   +7 more
openaire   +2 more sources