Results 131 to 140 of about 4,452,404 (339)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

Advanced Science, EarlyView.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao, Yuting Du, Danxia Zhou, Meng Bai, Xu Gao, Zhenyue Hao, Nan‐Jie Xu, Jiaqiang Liu, Ying Huang, Zhenji Gan, Jing Zhang   +10 more
wiley   +1 more source

Chemical modification of the allosteric and catalytic sites of fructose 1,6-diphosphatase. [PDF]

, 1966
O M Rosen, S. M. Rosen
openalex   +1 more source

Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.

Cancer Cell, 2020
Shuo Chen, Jiale Wu, Ying Liang, Yiwen Tang, Huaxin Song, Li-li Wu, Yangfei Xing, Ni Yan, Yuntong Li, Zhengyuan Wang, Shuhua Xiao, Xin Lu, Saisai Chen, Min Lu   +13 more
semanticscholar   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery [PDF]

, 2021
Sonia Huecas, Lidia Araújo‐Bazán, Federico M. Ruiz, Laura B. Ruiz-Ávila, R. Fernando Martínez, Andrea Escobar-Peña, Marta Artola, Henar Vázquez‐Villa, Mar Martín‐Fontecha, Carlos Fernández‐Tornero, María L. López-Rodrı́guez, José M. Andreu   +11 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Boosting Reversible Photocontrol of a Photoxenase by an Engineered Conformational Shift

Angewandte Chemie, EarlyView.
Photocontrol of enzymes with photoswitchable unnatural amino acids hitherto yielded only limited light‐regulation factors (LRFs). Here we boosted the LRF of an imidazole glycerol phosphate synthase variant from ∼15 to ∼100 in a semi‐rational design approach and unraveled the mechanistic fundamentals of this effect via biophysical and computational ...
Sabrina Mandl, Janet Sánchez, Miquel Estévez, Astrid Bruckmann, Caroline Hiefinger, Sílvia Osuna, Andrea Hupfeld   +6 more
wiley   +2 more sources

A Modular Biosensor Platform for the Detection of Plastic Monomers and the Engineering of Promiscuous Amidases Toward Challenging Substrates

Advanced Science, EarlyView.
A luciferase is used as biosensor for aldehydes, produced enzymatically from different monomeric building blocks of plastics like polyurethanes (PUs). The screening platform is used to monitor esterase, amidase, and urethanase activity and to guide the selection of enzyme variants with improved hydrolytic activities toward difficult to hydrolyze ...
Ina Somvilla, Hannah Meier, Florian Oehlschläger, Hannes Meinert, Lena Koch, Patrick Ihrle, Katharina M. Mehnert, Morten Flieger, Jonas Boß, Marco Seifert, Dominique Böttcher, Uwe T. Bornscheuer, Thomas Bayer   +12 more
wiley   +1 more source

Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins

Angewandte Chemie, EarlyView.
Random hetero oligomers (RHOs) of defined compositions are synthesized and fractionated to identify the chemical design criteria (charge, length, hydrophobicity) required to achieve nanomolar binding to green fluorescent protein, resulting in >100% fluorescence increases.
Darwin C. Gomez, Swarnadeep Seth, Ronnie Mondal, Stephen J. Koehler, Jared G. Baker, Charles Plate, Ian C. Anderson, Mikayla R. Smith, Joey Gloriod, Morgan Gunter, Valerie V. Welborn, Sanket A. Deshmukh, C. Adrian Figg   +12 more
wiley   +2 more sources