Advanced Science, EarlyView.This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang +3 more
wiley +1 more source
Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase
Nature CommunicationsDual-specificity mitogen-activated protein kinase (MAPK) phosphatases (MKPs) directly dephosphorylate and inactivate the MAPKs. Although the catalytic mechanism of dephosphorylation of the MAPKs by the MKPs is established, a complete molecular picture of
Erin Skeens +8 more
doaj +1 more source
Targeted Medical Therapies for Vascular Anomalies: A Clinical Review
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Vascular anomalies represent a broad spectrum of disorders characterized by aberrant blood or lymphatic vessel development, which can lead to complex clinical phenotypes. Historically, vascular anomalies were classified solely on the basis of their clinical and histopathologic features.
Whitney Eng
wiley +1 more source
Structural insight to mutation effects uncover a common allosteric site in class C GPCRs [PDF]
, 2016 Kasper Harpsøe +4 more
openalex +1 more source
Binding Modes of Xanthine-Derived Selective Allosteric Site Inhibitors of MTHFD2. [PDF]
ChemistryOpen, 2023 Jha V, Eriksson LA.
europepmc +1 more source
Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa [PDF]
, 2019 Yassmin Abdelhamid +5 more
openalex +1 more source
PharmaceuticalsPositive allosteric modulators (PAMs) of the cannabinoid CB1 receptor (CB1) offer potential therapeutic advantages in the treatment of neuropathic pain and addiction by avoiding the adverse effects associated with orthosteric CB1 activation.
Hayley M. Green +4 more
doaj +1 more source
Retraction: The Rational Design of Specific Peptide Inhibitor against p38α MAPK at Allosteric-Site: A Therapeutic Modality for HNSCC. [PDF]
PLoS One, 2023 PLOS ONE Editors.
europepmc +1 more source
Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases. [PDF]
Protein Sci, 2023 Marcos-Viquez J +7 more
europepmc +1 more source