Results 81 to 90 of about 4,452,404 (339)

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors

Bioinformatics and Biology Insights, 2021
G-protein-coupled receptors (GPCRs) are membrane proteins which play an important role in many cellular processes and are excellent drug targets. Despite the existence of several US Food and Drug Administration (FDA)-approved GPCR-targeting drugs, there ...
K Harini, S Jayashree, Vikas Tiwari, Sneha Vishwanath, Ramanathan Sowdhamini   +4 more
doaj   +1 more source

The Anisotropic Adsorption of De Novo Allosteric Two‐Component Protein Fibers on Mica Surfaces

Advanced Functional Materials, EarlyView.
In this study, the interfacial behavior of de novo designed proteins that self‐assemble into tubular architectures with distinct morphologies — small (S), large (L), and helical (H) fibers — at the muscovite mica‐water interface is explored using in situ AFM. Abstract Protein adsorption at solid–liquid interfaces underlies many biomedical and materials
Chenyang Shi, Hao Shen, Yuna Bae, Jaeyoung Heo, Shuai Zhang, Lehan Yao, David Baker, James J De Yoreo   +7 more
wiley   +1 more source

Aptamer‐Based DNA Allosteric Switch for Regulation of Protein Activity

Advanced Science
Allostery is a fundamental way to regulate the function of biomolecules playing crucial roles in cell metabolism and proliferation and is deemed the second secret of life.
Hongzhi Sun, Di Zhao, Yating He, Hong‐Min Meng, Zhaohui Li   +4 more
doaj   +1 more source

Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using ᴅ-Amino Acids. [PDF]

PLoS ONE, 2016
Chirality plays a major role in recognition and interaction of biologically important molecules. The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) is the first enzyme of the shikimate pathway, which is responsible for the synthesis
Sebastian Reichau, Nicola J Blackmore, Wanting Jiao, Emily J Parker   +3 more
doaj   +1 more source

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity*

Journal of Biological Chemistry, 2016
Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some ...
Kyle W. Anderson, Natalia Mast, J. W. Hudgens, Joseph B Lin, I. Turko, I. Pikuleva   +5 more
semanticscholar   +1 more source

Surface Sites for Engineering Allosteric Control in Proteins [PDF]

Science, 2008
Statistical analyses of protein families reveal networks of coevolving amino acids that functionally link distantly positioned functional surfaces. Such linkages suggest a concept for engineering allosteric control into proteins: The intramolecular networks of two proteins could be joined across their surface sites such that the activity ...
Jeeyeon, Lee, Madhusudan, Natarajan, Vishal C, Nashine, Michael, Socolich, Tina, Vo, William P, Russ, Stephen J, Benkovic, Rama, Ranganathan   +7 more
openaire   +2 more sources

Novel 3D‐Printed Biophotonic Scaffold Displaying Luminescence under Near‐Infrared Light for Photopharmacological Activation and Biological Signaling Compound Release

Advanced Healthcare Materials, EarlyView.
Despite significant efforts in developing novel biomaterials to regenerate tissue, only a few of them have successfully reached clinical use. It has become clear that the next generation of biomaterials must be multifunctional. Smart biomaterials can respond to environmental or external stimuli, interact in a spatial‐temporal manner, and trigger ...
Sonya Ghanavati, Ekin Opar, Virginia Alessandra Gobbo, Carlo Matera, Fabio Riefolo, Rossella Castagna, Julien Colombelli, Andrew Draganski, Joshua Baggott, Mika Lastusaari, Pau Gorostiza, Laeticia Petit, Jonathan Massera   +12 more
wiley   +1 more source

Allosteric Lever: Toward a Principle of Specific Allosteric Response

Physical Review X
Allostery, the phenomenon by which the perturbation of a molecule at one site alters its behavior at a remote functional site, enables control over biomolecular function.
Maximilian Vossel, Bert L. de Groot, Aljaž Godec   +2 more
doaj   +1 more source

Identification of a Novel Inhibitory Allosteric Site in p38α

PLOS ONE, 2016
In the present study, we report the discovery of a novel allosteric inhibitory site for p38α, a subclass of the mitogen-activated protein kinases (MAPK) family. The putative site was discovered after inspection of the crystallographic structure of the p38α-MK2 complex.
Patricia Gomez-Gutierrez, Pedro M Campos, Miguel Vega, Juan J Perez   +3 more
openaire   +4 more sources