Results 1 to 10 of about 18,737 (212)
Convergent allostery in ribonucleotide reductase [PDF]
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to ...
William C. Thomas +7 more
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Eigenvector Centrality Distribution for Characterization of Protein Allosteric Pathways
, 2018 Determining the principal energy pathways for allosteric communication in biomolecules, that occur as a result of thermal motion, remains challenging due to the intrinsic complexity of the systems involved.
Batista, Victor S. +8 more
core
NMR Line Shapes and Multi-State Binding Equilibria [PDF]
, 2012 Biological function of proteins relies on conformational transitions and binding of specific ligands. Protein-ligand interactions are thermodynamically and kinetically coupled to conformational changes in protein structures as conceptualized by the ...
Kovrigin, Evgeni
core +1 more source
Domain insertion permissibility-guided engineering of allostery in ion channels
Nature Communications, 2019 Allostery is a fundamental principle of protein regulation that remains challenging to engineer. Here authors screen human Inward Rectifier K + Channel Kir2.1 for permissibility to domain insertions and propose that differential permissibility is a ...
Willow Coyote-Maestas +3 more
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Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor
eLife, 2018 Organisms adapt to environmental cues using diverse signaling networks. In order to sense and integrate light for regulating various biological functions, photoreceptor proteins have evolved in a modular way.
Geoffrey Gourinchas +2 more
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The step-wise pathway of septin hetero-octamer assembly in budding yeast
eLife, 2017 Septin proteins bind guanine nucleotides and form rod-shaped hetero-oligomers. Cells choose from a variety of available septins to assemble distinct hetero-oligomers, but the underlying mechanism was unknown.
Andrew Weems, Michael McMurray
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An interdomain sector mediating allostery in Hsp70 molecular chaperones
Molecular Systems Biology, 2010 Allosteric coupling between protein domains is fundamental to many cellular processes. For example, Hsp70 molecular chaperones use ATP binding by their actin‐like N‐terminal ATPase domain to control substrate interactions in their C‐terminal substrate ...
Robert G Smock +6 more
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, 2011 S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents.
Choi, Sun +3 more
core +1 more source
Introduction to Protein Structure Prediction [PDF]
, 2017 This chapter gives a graceful introduction to problem of protein three- dimensional structure prediction, and focuses on how to make structural sense out of a single input sequence with unknown structure, the 'query' or 'target' sequence.
Abeln, Sanne +2 more
core +1 more source
Controlled mechanochemical coupling of anti-junctions in DNA origami arrays
Nature CommunicationsAllostery is a hallmark of cellular function and important in every biological system. Still, we are only starting to mimic it in the laboratory. Here, we introduce an approach to study aspects of allostery in artificial systems.
Fiona Cole +5 more
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