Results 111 to 120 of about 18,737 (212)

Coevolving residues distant from the ligand binding site are involved in GAF domain function

Communications Chemistry
Ligand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. However, the specific residues
Wesam S. Ahmed, Anupriya M. Geethakumari, Asfia Sultana, Anmol Tiwari, Tausif Altamash, Najla Arshad, Sandhya S. Visweswariah, Kabir H. Biswas   +7 more
doaj   +1 more source

A Footnote on Allostery

Journal of Molecular Biology, 2013
A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques Monod in 1965. Monod transmitted a copy of the manuscript, upon which he had written several comments, to Jean-Pierre Changeux, then a post-doctoral fellow at the University of California Berkeley in the laboratory of Howard Schachman.
Crick, F.H.C., Wyman, Jeffries
openaire   +2 more sources

Exploring allostery’s advantages [PDF]

C&EN Global Enterprise, 2019
Drug hunters have spent years cutting chemical keys to fit the most obvious biological locks: a protein’s active site, the spot where its natural substrate clicks in to turn it on or off. Walk into any big pharma company lab, and you will find the first step of that process: crane-like robotic arms pipetting tiny drops of compounds onto well plates ...
openaire   +1 more source

Structural and dynamic impacts of single-atom disruptions to guide RNA interactions within the recognition lobe of Geobacillus stearothermophilus Cas9

eLife
The intuitive manipulation of specific amino acids to alter the activity or specificity of CRISPR-Cas9 has been a topic of great interest. As a large multi-domain RNA-guided endonuclease, the intricate molecular crosstalk within the Cas9 protein hinges ...
Helen B Belato, Alexa L Knight, Alexandra M D'Ordine, Chinmai Pindi, Zhiqiang Fan, Jinping Luo, Giulia Palermo, Gerwald Jogl, George P Lisi   +8 more
doaj   +1 more source

Is allostery a fuzzy concept?

FEBS Open Bio
Allostery is an important property of biological macromolecules which regulates diverse biological functions such as catalysis, signal transduction, transport, and molecular recognition.
Veronica Morea, Francesco Angelucci, Andrea Bellelli   +2 more
doaj   +1 more source

Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction

, 2017
Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its input-output response.
Barnes, Stephanie L., Belliveau, Nathan M., Chure, Griffin, Einav, Tal, Lewis, Mitchell, Phillips, Rob, Razo-Mejia, Manuel   +6 more
core  

Protein allostery [PDF]

Acta Crystallographica Section A Foundations and Advances, 2020
openaire   +1 more source

The Power of Protein Dynamics in Binding and Allostery. [PDF]

Biochemistry
Lee AL, Sapienza PJ.
europepmc   +1 more source

Loop dynamics, allostery, and function in protein tyrosine phosphatases: insights from molecular simulations. [PDF]

Biochem Soc Trans
Welsh CL, Kamerlin SCL.
europepmc   +1 more source

Allosteric drugs in biomolecular condensates: ways forward. [PDF]

Drug Discov Today
Nussinov R, Regev C, Jang H.
europepmc   +1 more source