Results 11 to 20 of about 18,737 (212)
Fc-Binding Cyclopeptide Induces Allostery from Fc to Fab: Revealed Through in Silico Structural Analysis to Anti-Phenobarbital Antibody [PDF]
FoodsAllostery is a fundamental biological phenomenon that occurs when a molecule binds to a protein’s allosteric site, triggering conformational changes that regulate the protein’s activity.
Tao Zhou +6 more
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Combinatorial Control through Allostery [PDF]
The Journal of Physical Chemistry B, 2018 Many instances of cellular signaling and transcriptional regulation involve switch-like molecular responses to the presence or absence of input ligands. To understand how these responses come about and how they can be harnessed, we develop a statistical ...
Einav, Tal +3 more
core +10 more sources
Biology DirectIt was a Lucky Strike to be working with Eraldo Antonini on hemoglobin and myoglobin when Jeffries Wyman arrived in Rome in 1961. I found myself connected with a number of creative scientists when the concept of allosteric control was conceived and ...
Maurizio Brunori
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Bioswitches: Towards programmable, on-demand control of therapeutic proteins. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Wolf B, Mathony J, Niopek D.
europepmc +2 more sources
Structurally distributed surface sites tune allosteric regulation
eLife, 2021 Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the mutations that tune allostery. Are these mutations few or abundant, structurally localized or distributed?
James W McCormick +4 more
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Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles
Biomolecules, 2022 Allostery—regulation at distant sites is a key concept in biology. The proteasome exhibits multiple forms of allosteric regulation. This regulatory communication can span a distance exceeding 100 Ångstroms and can modulate interactions between the two ...
Philip Coffino, Yifan Cheng
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Allostery: An Overview of Its History, Concepts, Methods, and Applications. [PDF]
PLoS Computational Biology, 2016 The concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904) to the birth of allostery by Monod and Jacob (1961 ...
Jin Liu, Ruth Nussinov
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Biophysical Journal, 2016 G-protein-coupled receptors (GPCRs) constitute a large group of integral membrane proteins that transduce extracellular signals from a wide range of agonists into targeted intracellular responses. Although the responses can vary depending on the category of G-proteins activated by a particular receptor, responses were also found to be triggered by ...
Stuart J, Edelstein +1 more
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Trends in Genetics, 2014 Allosteric proteins have great potential in synthetic biology, but our limited understanding of the molecular underpinnings of allostery has hindered the development of designer molecules, including transcription factors with new DNA-binding or ligand-binding specificities that respond appropriately to inducers.
Raman, Srivatsan +4 more
openaire +3 more sources
Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations. [PDF]
PLoS Computational Biology, 2016 Molecular dynamics (MD) simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties of another site on the protein.
Samuel Hertig +2 more
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