Results 71 to 80 of about 42,423 (256)

Protein O‐GlcNAcylation in Health and Diseases

MedComm, Volume 6, Issue 12, December 2025.
We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran, Chuanbao Chen, Jingfeng Ou, Guanyi Wu, Chao Yang, Xiaoyou Liu   +5 more
wiley   +1 more source

THE EFFECT OF BLACK CUMIN SEED (Nigella Sativa L.) EXTRACT TO ALLOXAN INDUCES PANCREATIC TISSUE CATALASE ENZYME ACTIVITY OF MALE WISTAR RATS (Rattus norvegicus)

Jurnal Ilmiah Kedokteran Wijaya Kusuma, 2018
Alloxan causes the formation of reactive oxygen through the reduction process of alloxan (dialuric acid) in the β cells of pancreas. Free radicals cause damage  and decrease catalase enzyme activity.
qonita achmad, Irmawati Dikman, Sulistiana Prabowo   +2 more
doaj  

Effect of VCO to leucocyte differential count, glucose levels and blood creatinine of hyperglycemic and ovalbumin sensitized Mus musculus Balb/c [PDF]

, 2009
Abstrak. Handajani NS, Dharmawan R. 2009. Pengaruh VCO terhadap hitung jenis leukosit, kadar glukosa dan kreatinin darah Mus musculus Balb/c hiperglikemi dan tersensitisasi ovalbumin. Nusantara Bioscience 1: 1-8.
DHARMAWAN, RUBEN, HANDAJANI, NOOR SOESANTI   +1 more
core   +2 more sources

Bacteria‐Targeted Single‐Atom Nanozyme With Photothermal‐Augmented Multi‐Enzymatic Cascade and NO Delivery for Enhanced Infected Wound Healing

Advanced Science, Volume 12, Issue 42, November 13, 2025.
A single‐atom nanozyme‐based multifunctional nanoplatform synergizes bacterial targeting with a NIR‐II responsive therapeutic cascade for effective diabetic wound management. This nanoplatform enhances biofilm destruction through photothermal‐augmented biocatalysis while simultaneously activating endothelial cells by delivering nitric oxide to promote ...
Junyang Chen, Qing Chen, Xudong Qin, Haixia Yang, Xin Wang, Jianliang Zhou, Ying‐Wei Yang, Jian Tian   +7 more
wiley   +1 more source

Effect of Combined Leaf Extracts of Vernonia amygdalina (Bitter Leaf) and Gongronema latifolium (Utazi) on the Pancreatic beta-Cells of Streptozotocin- Induced Diabetic Rats [PDF]

, 2011
The study evaluated the effect of combined extracts of Vernonia amygdalina (VA) and Gongronema latifolium (GL) on the pancreas of streptozotocin (STZ) induced diabetic Wistar rats. Thirty-two (32) albino rats were divided equally into 4 groups.
Akpantah, Amabe, Akpaso, Mfon I, Atangwho, Item J, Ebong, Patrick E, Fischer, Victor A, Igiri, Anozeng O.   +5 more
core   +1 more source

A Comprehensive Review of Germination Impact on Moringa Seeds and Sprouts: Physiological and Biochemical Changes, Bioactive Compounds, Health Benefits, and Food Applications

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 6, November 2025.
ABSTRACT Germination is emerging as a promising bioprocess to produce edible moringa sprouts with enhanced nutritional value and health benefits. Germinated moringa seeds could be marketed as a novel food ingredient for functional food formulations. Attempts to understand the bioactive compounds and their associated health benefits of moringa seeds and
Yi Liu, Yi Kai, Dejian Huang, Shao Quan Liu, Yuyun Lu   +4 more
wiley   +1 more source

Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship?

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
Circadian rhythm is offering novel insights into the pathogenesis of retinopathy. Bmal1, a key transcriptional regulator of the circadian clock, serves as a critical pathologic cofactor in retinal degeneration. Deficiency in Bmal1 contributes to a broad spectrum of retinal pathological alterations, and modulating the clock gene Bmal1 could potentially ...
Yongheng Cui, Haoyan Li, Wenhui Fan, Hao Wu, Jiale Wang, Chengkang Qu, Ning Pu, Ye Tao   +7 more
wiley   +1 more source

PENGARUH TINGGINYA KADAR GULA PADA TIKUS PUTIH (Rattus \ud norvegicus) STRAIN WISTAR DIINJEKSI ALLOXAN TERHADAP \ud PENINGKATAN NEKROSIS NEURON OTAK [PDF]

, 2009
Background of Study: Epidemiology researches show that the increasing of diabetes mellitus incident will be followed by the raise of diabetes mellitus chronic complication, one of which is the destruction of brain neuron.
MAYA SANDY, IKA
core  

Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li, Hongrui Qin, Min Jiang, Hongjiang Wei, Hongyong Zhao, Ping Tang, Guangyu Jian, Henny C van der Mei, Tao Chen   +8 more
wiley   +1 more source

Effects of Methanolic Extract and Commercial Oil of Nigella sativa L. on Blood Glucose and Antioxidant Capacity in Alloxan-Induced Diabetic Rats

Pteridines, 2007
Nigella sativa is a medicinal plant widely used in the Arabic and Islamic world against a number of human pathologies. In this present study the methanol extraction (85 % then 50 %) of plant seeds gave an important yield of 27 % of dry substance.
Houcher Zahira, Boudiaf Khaouther, Benboubetra Mustapha, Houcher Bakhouche   +3 more
doaj   +1 more source