Results 61 to 70 of about 656,245 (262)
Almost surely constrained convex optimization
, 2019 We propose a stochastic gradient framework for solving stochastic composite convex optimization problems with (possibly) infinite number of linear inclusion constraints that need to be satisfied almost surely. We use smoothing and homotopy techniques to handle constraints without the need for matrix-valued projections.
Fercoq, Olivier +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
About the cause of the stimulative effect of humate in yeast cultures
Acta Societatis Botanicorum Poloniae, 2015 Trials were undertaken to elucidate the stimulating effect of sodium humate on yeast multiplication and the intensity of their fermentation. This effect appears specifically at pH non-optimal for the medium.
S. Gumiński, J. Sulej
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
An Almost Optimal Edit Distance Oracle
, 2021 We consider the problem of preprocessing two strings $S$ and $T$, of lengths $m$ and $n$, respectively, in order to be able to efficiently answer the following queries: Given positions $i,j$ in $S$ and positions $a,b$ in $T$, return the optimal alignment of $S[i \mathinner{.\,.} j]$ and $T[a \mathinner{.\,.} b]$. Let $N=mn$.
Charalampopoulos, Panagiotis +3 more
openaire +4 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
On the Weighted Mixed Almost Unbiased Ridge Estimator in Stochastic Restricted Linear Regression
Journal of Applied Mathematics, 2013 We introduce the weighted mixed almost unbiased ridge estimator (WMAURE) based on the weighted mixed estimator (WME) (Trenkler and Toutenburg 1990) and the almost unbiased ridge estimator (AURE) (Akdeniz and Erol 2003) in linear regression model.
Chaolin Liu, Hu Yang, Jibo Wu
doaj +1 more source
Representing graphs implicitly using almost optimal space
Discrete Applied Mathematics, 2001 The authors present a new graph labelling scheme that assigns to each vertex \(v\) of degree \(\delta(v)\) of a graph of order \(n\) a \(O(\delta(v)\log^2n)\) bit label. The adjacency test can be performed in seven steps and the entire scheme can be computed in polynomial time. In addition, the scheme is implicit (without pointers).
TALAMO, MAURIZIO, Vocca, P.
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source