Results 71 to 80 of about 701,199 (295)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Uniform hypergraphs containing no grids
, 2013 A hypergraph is called an r×r grid if it is isomorphic to a pattern of r horizontal and r vertical lines, i.e.,a family of sets {A1, ..., Ar, B1, ..., Br} such that Ai∩Aj=Bi∩Bj=φ for 1 ...
Füredi, Zoltán, Ruszinkó, Miklós
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Electronic Journal of Differential Equations, 2015 In this article, we are interested in singularly perturbed nonlinear elliptic problems involving a fractional Laplacian. Under a class of nonlinearity which is believed to be almost optimal, we construct a positive solution which exhibits multiple ...
Jinmyoung Seok
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
About predictions in spatial autoregressive models: optimal and almost optimal strategies [PDF]
, 2017 About predictions in spatial autoregressive models: optimal and almost optimal strategies. Spatial Economic Analysis. This paper addresses the problem of prediction in the spatial autoregressive (SAR) model for areal data, which is classically used in ...
Goulard, Michel +6 more
core +1 more source
Robust empirical optimization is almost the same as mean–variance optimization
Operations Research Letters, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jun-ya Gotoh +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
We consider the optimal control of a PDE with random source term subject to probabilistic or almost sure state constraints. In the main theoretical result, we provide an exact formula for the Clarke subdifferential of the probability function without a ...
Geiersbach, Caroline +2 more
core +1 more source