Results 61 to 70 of about 701,199 (295)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Weak almost periodic and optimal mild solutions of fractional evolution equations

open access: yesElectronic Journal of Differential Equations, 2009
In this article, we prove the existence of optimal mild solutions for linear fractional evolution equations with an analytic semigroup in a Banach space.
Amar Debbouche, Mahmoud M. El-Borai
doaj  

Expander Decomposition with Almost Optimal Overhead

open access: yesCoRR
We present the first polynomial-time algorithm for computing a near-optimal \emph{flow}-expander decomposition. Given a graph $G$ and a parameter $ϕ$, our algorithm removes at most a $ϕ\log^{1+o(1)}n$ fraction of edges so that every remaining connected component is a $ϕ$-\emph{flow}-expander (a stronger guarantee than being a $ϕ$-\emph{cut}-expander ...
Nikhil Bansal 0001   +2 more
openaire   +2 more sources

Robust Weighted Timed Automata and Games [PDF]

open access: yes, 2013
Weighted timed automata extend timed automata with cost variables that can be used to model the evolution of various quantities. Although cost-optimal reachability is decidable (in polynomial space) on this model, it becomes undecidable on weighted ...
Markey, Nicolas   +5 more
core   +1 more source

Almost supplementary difference sets and quaternary sequences with optimal autocorrelation [PDF]

open access: yes, 2020
We introduce almost supplementary difference sets (ASDS). For odd m, certain ASDS in Zm that have amicable incidence matrices are equivalent to quaternary sequences of odd length m with optimal autocorrelation. As one consequence, if 2m − 1 is a prime
Flannery, D. L.   +1 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Robust monetary policy in a currency union [PDF]

open access: yesPanoeconomicus, 2012
A great number of recent researches have found importance of country specific shocks for optimal monetary policy construction in the context of a currency union.
Kuznetsova Olga
doaj   +1 more source

Almost surely constrained convex optimization

open access: yes, 2019
We propose a stochastic gradient framework for solving stochastic composite convex optimization problems with (possibly) infinite number of linear inclusion constraints that need to be satisfied almost surely. We use smoothing and homotopy techniques to handle constraints without the need for matrix-valued projections.
Olivier Fercoq   +3 more
openaire   +3 more sources

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