Results 91 to 100 of about 1,064,326 (320)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Almost periodic functions, constructively [PDF]
Logical Methods in Computer Science, 2005 The almost periodic functions form a natural example of a non-separable normed space. As such, it has been a challenge for constructive mathematicians to find a natural treatment of them. Here we present a simple proof of Bohr's fundamental theorem for almost periodic functions which we then generalize to almost periodic functions on general ...
openaire +5 more sources
Approximate Correctors and Convergence Rates in Almost-Periodic Homogenization [PDF]
, 2016 We carry out a comprehensive study of quantitative homogenization of second-order elliptic systems with bounded measurable coefficients that are almost-periodic in the sense of H. Weyl.
Zhongwei Shen, Jinping Zhuge
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2015 In this paper, we study a class of Lasota-Wazewska model with distributed delays, new criteria for the existence and global asymptotic stability of positive pseudo almost periodic solutions are established by using the fixed point method and the ...
Zhiwen Long
doaj +1 more source
Completely almost periodic functionals [PDF]
Archiv der Mathematik, 2011 8 pages; some ...
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Block Toeplitz operators with frequency-modulated semi-almost periodic symbols
International Journal of Mathematics and Mathematical Sciences, 2003 This paper is concerned with the influence of frequency modulation on the semi-Fredholm properties of Toeplitz operators with oscillating matrix symbols.
A. Böttcher, S. Grudsky, I. Spitkovsky
doaj +1 more source
Advances in Difference Equations, 2017 In this paper, we build a multispecies predator-prey model with mutual interference and time delays. By means of the comparison theorem, Ascoli theorem and Lebesgue dominated convergence theorem, we establish the sufficient conditions of permanence and ...
Qin Liu +4 more
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