Results 101 to 110 of about 7,009,663 (303)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Duality properties and Riesz representation theorem in the Besicovitch-Orlicz space of almost periodic functions [PDF]

open access: yes, 2002
summary:In [6], the classical Riesz representation theorem is extended to the class of Besicovitch space of almost periodic functions $B^{q}$\,a.p., $q\in ] 1,+\infty [$ . It is also shown that this space is reflexive. We shall consider here such results
Boulahia, F., Morsli, M., Bedouhene, F.
core   +1 more source

Composition and convolution theorems for mu-Stepanov pseudo almost periodic functions and applications to fractional integro-differential equations

open access: yesElectronic Journal of Differential Equations, 2018
In this article we establish new convolution and composition theorems for $\mu$-Stepanov pseudo almost periodic functions. We prove that the space of vector-valued $\mu$-Stepanov pseudo almost periodic functions is a Banach space. As an application,
Edgardo Alvarez
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

On computing minimal realizations of periodic descriptor systems [PDF]

open access: yes, 2007
: We propose computationally efficient and numerically reliable algorithms to compute minimal realizations of periodic descriptor systems. The main computational tool employed for the structural analysis of periodic descriptor systems (i.e., reachability
Andras Varga, Varga, Andreas
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Existence and uniqueness of pseudo almost periodic solutions for Lienard-type systems with delays

open access: yesElectronic Journal of Differential Equations, 2016
This article concerns Lienard-type systems with time-varying delays. By applying the theory of exponential dichotomies, the properties of pseudo almost periodic function, inequality analysis techniques, and contraction mapping principle, new criteria ...
Changjin Xu, Maoxin Liao
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Persistence of Li–Yorke chaos in systems with relay

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2017
It is rigorously proved that the chaotic dynamics of the non-smooth system with relay function is persistent even if a chaotic perturbation is applied.
Marat Akhmet   +2 more
doaj   +1 more source

Computation of minimal periodic realizations of transfer-function matrices [PDF]

open access: yes, 2003
We present a numerical approach to compute a minimal periodic state-space realization of a transfer-function matrix corresponding to a lifted state-space representation.
Varga, A., Varga, Andras
core  

Home - About - Disclaimer - Privacy