Results 121 to 130 of about 1,064,326 (320)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Composition and convolution theorems for mu-Stepanov pseudo almost periodic functions and applications to fractional integro-differential equations

Electronic Journal of Differential Equations, 2018
In this article we establish new convolution and composition theorems for $\mu$-Stepanov pseudo almost periodic functions. We prove that the space of vector-valued $\mu$-Stepanov pseudo almost periodic functions is a Banach space. As an application,
Edgardo Alvarez
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Persistence of Li–Yorke chaos in systems with relay

Electronic Journal of Qualitative Theory of Differential Equations, 2017
It is rigorously proved that the chaotic dynamics of the non-smooth system with relay function is persistent even if a chaotic perturbation is applied.
Marat Akhmet, Mehmet Onur Fen, Ardak Kashkynbayev   +2 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Existence and uniqueness of pseudo almost periodic solutions for Lienard-type systems with delays

Electronic Journal of Differential Equations, 2016
This article concerns Lienard-type systems with time-varying delays. By applying the theory of exponential dichotomies, the properties of pseudo almost periodic function, inequality analysis techniques, and contraction mapping principle, new criteria ...
Changjin Xu, Maoxin Liao
doaj  

N-dimensional almost periodic functions II

Revista de Matemática: Teoría y Aplicaciones, 2003
In this paper we continue the research begun in [CA-2]. Some new results are shown and proven, like the structure theorem for n-dimensional almost periodic functions by using the Bochner Transform. Also, the Haraux [Har] condition in the n-dimensional case, and some topological theorems similar to Bochner and Ascoli theorems.
Arguedas, Vernor, Castro, Edwin
openaire   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

On the existence of almost periodic solutions for a class of neutral delay differential equations

, 2014
International audienceWe study the existence of a Besicovitch almost periodic solution for a class of second order neutral delay differential equations u''(t−r)+D_1F(u(t−r),u(t−2r),t−r)+D_2F(u(t),u(t−r),t) = 0, in a Hilbert space, under some hyptoheses on
Ayachi, Moez, Lassoued, Dhaou
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source