Results 81 to 90 of about 451,129 (278)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Almost automorphic and pseudo almost periodic solutions to damped Euler–Lagrange equations

Examples and Counterexamples
This paper investigates the existence of almost automorphic, asymptotically almost automorphic, pseudo almost automorphic, and pseudo almost periodic solutions to damped Euler–Lagrange equations.
Bouadi Abdelkader, Boudjema Souhila, Houmia Anouar   +2 more
doaj   +1 more source

Almost periodic behavior of solutions of a nonlinear Volterra system, 2 [PDF]

Almost periodic behavior of solutions of nonlinear Volterra ...
Miller, R. K.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Almost Periodic (Type) Solutions to Parabolic Cauchy Inverse Problems

Abstract and Applied Analysis, 2012
We first show the existence and uniqueness of (pseudo) almost periodic solutions of some types of parabolic equations. Then, we apply the results to a type of Cauchy parabolic inverse problems and show the existence, uniqueness, and stability.
Fenglin Yang, Chuanyi Zhang
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Boundedness and almost periodicity for some state-dependent delay differential equations

Electronic Journal of Differential Equations, 2002
This work is devoted to the study the existence and uniqueness of bounded solutions for state-dependent delay differential equations. We also study the existence of periodic and almost periodic solutions.
El Hadi Ait Dads, Khalil Ezzinbi
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Decay estimate of viscosity solutions of nonlinear parabolic PDEs and applications

Le Matematiche, 2014
The aim of this paper is to establish a decay estimate for viscosity solutions of nonlinear PDEs. As an application we prove existence and uniqueness for time almost periodic viscosity solutions.
Silvana Marchi
doaj  

Almost Periodicity of Mild Solutions of Inhomogeneous Periodic Cauchy Problems

Journal of Differential Equations, 1999
The authors consider a mild solution \(u\) to the well-posed inhomogeneous Cauchy problem \[ u'(t)= A(t)u(t)+ f(t), \] on a Banach space \(X\), where \(A(\cdot)\) is periodic. For a problem on \(\mathbb{R}_+\) the authors show that \(u\) is asymptotically almost-periodic if \(f\) is asymptotically almost-periodic, \(u\) is bounded, uniformly continuous
Batty, C, Hutter, W, Rabiger, F
openaire   +3 more sources