Results 11 to 20 of about 24,353 (197)

Emodin and Aloe-Emodin Reduce Cell Growth and Disrupt Metabolic Plasticity in Human Melanoma Cells. [PDF]

Nutrients
Background/Objectives: Melanoma is an aggressive skin cancer with intratumor metabolic heterogeneity, which drives its progression and therapy resistance. Natural anthraquinones, such as emodin and aloe-emodin, exhibit anti-cancer properties, but their effects on metabolic plasticity remain unclear.
Baldassari F, Bonanomi M, Mallia S, Bonas M, Brivio E, Aramini T, Porro D, Gaglio D.   +7 more
europepmc   +6 more sources

In vitro and in vivo antileishmanial effects of aloe-emodin on Leishmania major [PDF]

Journal of Traditional and Complementary Medicine, 2015
Cutaneous leishmaniasis is a common parasitic disease that is endemic in some parts of Iran. The drugs of choice used for leishmaniasis therapy are associated with a risk of recurrence and serious adverse effects. Therefore, finding a safe and effective treatment is of great importance.
Abdolhossein Dalimi, Mahdi Delavari, Fatemeh Ghaffarifar, Javid Sadraei   +3 more
doaj   +5 more sources

Inhibitory Mechanism of Aloe Emodin on α-Glucosidase and Synergistic Effect with Acarbose [PDF]

Shipin Kexue
In order to investigate the interaction between aloe emodin and α-glucosidase, enzyme kinetics, ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy and fluorescence spectroscopy were employed to investigate the inhibitory mechanism of aloe emodin ...
QIN Chaofeng, LI Jiao, HAO Jingwen, BU Yaqin, LI Sheng, CHEN Naidong
doaj   +3 more sources

Aloe-emodin glycosides of senna leaf

Journal of Pharmacy and Pharmacology, 1966
Abstract A new glucoside has been isolated from senna leaf (Cassia senna L.) and shown to be identical with the aloe-emodin-8-mono-β-D-glucoside recently isolated from Rheum palmatum. This new quinone glucoside is insoluble in water and is present in only small quantities and therefore unlikely to contribute much to the activity of the ...
J W, Fairbairn, A B, Shrestha
openaire   +3 more sources

Antiglycation Activity and HT-29 Cellular Uptake of Aloe-Emodin, Aloin, and Aloe arborescens Leaf Extracts [PDF]

Molecules, 2019
Aloe arborescens is a relevant species largely used in traditional medicine of several countries. In particular, the decoction of leaves is prepared for various medicinal purposes including antidiabetic care. The aim of this research was the study of the
Guglielmina Froldi, Federica Baronchelli, Elisa Marin, Margherita Grison   +3 more
doaj   +2 more sources

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

BMC Complementary and Alternative Medicine, 2017
Background In this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin and antiplasmodial activity of
Sandeep Kumar, Manila Yadav, Amita Yadav, Pooja Rohilla, Jaya Parkash Yadav   +4 more
doaj   +2 more sources

Aloe-emodin as drug candidate for cancer therapy

Oncotarget, 2018
As a leading cause of global mortality, cancer frequently cannot be cured due to the development of drug resistance. Therefore, novel drugs are required. Naturally occurring anthraquinones are mostly present in Rumex and Rhamnus species and are of interest because of their structural similarity to anthracyclines as well established anticancer drugs. In
ÖZENVER, NADİRE, DEMİREZER, LÜTFİYE ÖMÜR, EFFERTH, Thomas, SAEED, Mohamed   +3 more
openaire   +5 more sources

Novel Aloe-Emodin Derivatives as Potential Anticancer Agents: Synthesis, Characterization and Cytotoxic Activity. [PDF]

Molecules
The fusion of heterocycles onto an anthraquinone scaffold represents a promising strategy to optimize anticancer activity. This study has the aim to synthesize and characterize novel anthra[1,2-b]furan compounds based on the natural product aloe-emodin ...
Semerel J, Zheng S, Hu H, Fang Y, John N, Fardim P, Dehaen W.   +6 more
europepmc   +2 more sources

Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell [PDF]

British Journal of Pharmacology, 2001
This study demonstrated aloe‐emodin‐ and emodin‐induced apoptosis in lung carcinoma cell lines CH27 (human lung squamous carcinoma cell) and H460 (human lung non‐small cell carcinoma cell). Aloe‐emodin‐ and emodin‐induced apoptosis was characterized by nuclear morphological changes and DNA fragmentation.
Hong-Zin Lee
exaly   +3 more sources

Cell Metabolomics Reveals the Potential Mechanism of Aloe Emodin and Emodin Inhibiting Breast Cancer Metastasis. [PDF]

Int J Mol Sci, 2022
Metastasis is one of the main obstacles for the treatment and prognosis of breast cancer. In this study, the effects and possible mechanisms of aloe emodin (AE) and emodin (EMD) for inhibiting breast cancer metastasis were investigated via cell metabolomics.
Cheng G, Liu Z, Zheng Z, Song F, Zhuang X, Liu S.   +5 more
europepmc   +3 more sources