Results 91 to 100 of about 124,197,172 (205)
MedComm, Volume 7, Issue 11, November 2026.Graphical overview of bioinspired regenerative platforms designed to remodel the diseased lung microenvironment. These systems integrate gene addition, siRNA‐mediated transcript silencing, CRISPR‐based modulation, and base editing approaches to promote alveolar repair, AT2‐to‐AT1 regeneration, resolution of inflammation, and restoration of vascular ...
Kajal Kamra, Sonal Gaur, Jaswinder Singh
wiley +1 more source
Therapeutics: Gene Therapy for Alpha-1 Antitrypsin Deficiency
, 2017 This review seeks to give an overview of alpha-1 antitrypsin deficiency, including the different disease phenotypes that it encompasses. We then describe the different therapeutic endeavors that have been undertaken to address these different phenotypes.
Flotte, Terence R., Gruntman, Alisha M
core +1 more source
Journal of Education, Health and SportIntroduction: Alpha-1 antitrypsin (AAT) is a glycoprotein produced by liver, belonging to the serine protease inhibitor family. Alpha-1 antitrypsin deficiency (AATD) is very common autosomal recessive genetic disease caused by point mutation in ...
Dawid Kościołek +9 more
doaj +1 more source
Neutrophil Extracellular Traps: From Mechanistic Insights to Therapeutic Targeting
MedComm, Volume 7, Issue 11, November 2026.Neutrophil extracellular traps act as multimodal signal processors in cancer via three mechanisms: biomechanical scaffolds activating integrin–FAK signaling and excluding immune cells; immunometabolic hubs driving glycolysis and immunosuppression; and signal‐integration platforms synergistically activating oncogenic pathways.
Hongjie Fan +5 more
wiley +1 more source
Liver Organoids: From Disease Modelling to Regenerative Medicine
Cell Proliferation, Volume 59, Issue 11, November 2026.Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang +5 more
wiley +1 more source
Journal of Gastroenterology and Hepatology, Volume 41, Issue 11, Page 3557-3566, November 2026.ABSTRACT Background and Aim Alcohol‐associated liver disease frequently presents late as decompensated cirrhosis, representing a missed opportunity for intervention. Extrahepatic alcohol‐related presentations requiring acute care, such as alcohol‐associated pancreatitis and alcohol withdrawal syndrome, may identify heavy drinkers at varying risk for ...
Butros Fakhoury +5 more
wiley +1 more source
Alpha 1 Antitrypsin Deficiency (AATD) Financial Cost
Explore the financial burdens of Alpha-1 Antitrypsin Deficiency, offering insights into treatment costs, economic impact, and innovative healthcare ...
Azhar ul Haque Sario
core +1 more source
Alpha 1 antitrypsin deficiency in non cystic fibrosis bronchiectasis
Egyptian Journal of Chest Disease and Tuberculosis, 2013 Setting: It is important to identify manifestations of alpha1-antitrypsin deficiency (A1ATD) in bronchiectasis to improve care and outcome in these patients.
Mohamed Shahat Badawy +2 more
doaj +1 more source
Liver:: Alpha-1-Antitrypsin Deficiency.
, 1900 Alpha-1-antitrypsin deficiency. COMMENT: Bile stasis and a micronodular cirrhosis are seen in this example of enzyme deficiency disease.
MUSC Department of Pathology and Laboratory Medicine
core
PulmonologyIntroduction and objectives Asthma is a chronic inflammatory disease of the airways. Asthma patients may experience potentially life-threatening episodic flare-ups, known as exacerbations, which may significantly contribute to the asthma burden. The Pi*S
Elena Martín-González +27 more
doaj +1 more source