Results 81 to 90 of about 480,558 (290)

Genetic Variants of Serum Alpha 1 Antitrypsin [PDF]

, 1995
Complete absence of data on alpha 1 antitrypsin in this country prompted us to determine serum levels using radial immunodiffusion (RID) and phenotypes by isoelectric focusing (IEF) in 100 healthy adults (52 males and 48 females).
Shahid, Anjum, Siddiqui, Anwar Ali, Waqar, Mohammed Anwar, Zuberi, Sarwar J   +3 more
core   +1 more source

Experimental and investigational drugs for the treatment of alpha-1 antitrypsin deficiency

Expert Opinion on Investigational Drugs, 2019
Introduction: Alpha-1 antitrypsin deficiency (AATD) is most often associated with chronic lung disease, early onset emphysema, and liver disease. The standard of care in lung disease due to AATD is alpha-1 antitrypsin augmentation but there are several ...
A. Pye, A. Turner
semanticscholar   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis

Drug Design, Development and Therapy, 2011
Jennifer A Dickens, David A LomasDepartment of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, UKAbstract: Alpha-1-antitrypsin is the most abundant circulating protease inhibitor. It is
Dickens JA, Lomas DA
doaj  

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review

International Journal of COPD, 2017
Background Alpha-1 antitrypsin deficiency (AATD) is a rare genetic condition predisposing individuals to chronic obstructive pulmonary disease (COPD). The treatment is generally extrapolated from COPD unrelated to AATD; however, most COPD trials exclude ...
R. Edgar, Mitesh K. Patel, S. Bayliss, Diana Crossley, E. Sapey, A. Turner   +5 more
semanticscholar   +1 more source

Gross Intrahepatic Mass Formation Predicts the Primary Site of Perihilar Cholangiocarcinoma Based on Molecular Pathologic Studies

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Intrahepatic cholangiocarcinoma (iCCA) and extrahepatic cholangiocarcinoma (eCCA) are clinically and genetically distinct. However, the classification of perihilar cholangiocarcinoma (phCCA) with an intrahepatic tumor mass remains unclear.
Yuki Masuda, Naoto Kubota, Ryo Takemura, Yasuhito Arai, Yuta Abe, Osamu Itano, Minoru Esaki, Tatsuhiro Shibata, Yuko Kitagawa, Hidenori Ojima   +9 more
wiley   +1 more source

Diagnosis of alpha-1-antitrypsin deficiency by DNA analysis of children with liver disease

Arquivos de Gastroenterologia, 2001
Background - Alpha-1-antitrypsin deficiency is a genetic disorder which is transmitted in a co-dominant, autosomal form. Alpha-1-antitrypsin deficiency affects mainly the lungs and the liver leading, in the latter case, to neonatal cholestasis, chronic ...
De TOMMASO Adriana Maria Alves, ROSSI Cláudio Lúcio, ESCANHOELA Cecília Amélia Fazzio, SERRA Heliane Guerra, BERTUZZO Carmen Sílvia, HESSEL Gabriel   +5 more
doaj  

Pulse of inflammatory proteins in the pregnant uterus of European polecats (Mustela putorius) leading to the time of implantation [PDF]

, 2017
Uterine secretory proteins protect the uterus and conceptuses against infection, facilitate implantation, control cellular damage resulting from implantation, and supply pre-implantation embryos with nutrients.
Burchmore, Richard J.S., Kennedy, Malcolm W., Lindeberg, Heli   +2 more
core   +1 more source

5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency

Molecular Therapy, 2017
Alpha-1 antitrypsin deficiency is a monogenic disorder resulting in emphysema due principally to the unopposed effects of neutrophil elastase. We previously reported achieving plasma wild-type alpha-1 antitrypsin concentrations at 2.5%–3.8% of the ...
C. Mueller, Gwladys Gernoux, A. Gruntman, F. Borel, E. Reeves, R. Calcedo, Farshid N. Rouhani, A. Yachnis, M. Humphries, M. Campbell-Thompson, L. Messina, J. Chulay, B. Trapnell, James M. Wilson, N. McElvaney, T. Flotte   +15 more
semanticscholar   +1 more source