Results 61 to 70 of about 105,578,950 (193)

Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels

Communications Biology
Adiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated.
Andri Iona, Pang Yao, Alfred Pozarickij, Christiana Kartsonaki, Saredo Said, Neil Wright, Kuang Lin, Iona Millwood, Hannah Fry, Mohsen Mazidi, Baihan Wang, Yiping Chen, Huaidong Du, Ling Yang, Daniel Avery, Dan Schmidt, Dianjianyi Sun, Pei Pei, Jun Lv, Canqing Yu, Michael Hill, Junshi Chen, Fiona Bragg, Derrick Bennett, Robin Walters, Liming Li, Robert Clarke, Zhengming Chen, China Kadoorie Biobank Collaborative Group   +28 more
doaj   +1 more source

Endothelial thrombomodulin—Its role in trauma‐induced coagulopathy

Transfusion, Volume 66, Issue S1, Page S246-S256, May 2026.
Abstract Background Trauma‐induced coagulopathy (TIC) describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin‐protein C axis is central to the evolution of TIC. Soluble thrombomodulin (sTM) levels are elevated after injury and predict poor clinical outcomes.
Jeries Abu‐Hanna, Gael B. Morrow, Gang Xu, Lewis Timms, Naveed Akbar, Michael Laffan, Robin P. Choudhury, Nicola Curry   +7 more
wiley   +1 more source

Factor XIII Supplementation in Postpartum Hemorrhage: From Biological Rationale to Clinical Implementation

American Journal of Hematology, Volume 101, Issue 4, Page 794-806, April 2026.
ABSTRACT Postpartum hemorrhage (PPH) remains the leading cause of preventable maternal mortality despite standard interventions. Recent fibrinogen trials failed to improve outcomes, prompting interest in coagulation factor XIII (FXIII). FXIII functions as “molecular cement,” cross‐linking fibrin and stabilizing clots.
Jeremy W. Jacobs, Elizabeth A. Abels, Brian D. Adkins, Garrett S. Booth, Victoria Costa, Sheharyar Raza, Michelle Simon, Jennifer S. Woo, Allison P. Wheeler   +8 more
wiley   +1 more source

Hemostasis and blood requirements in orthotopic liver transplantation with and without high-dose aprotinin

Haematologica, 1998
BACKGROUND AND OBJECTIVE: Several factors seem to lead to considerable bleeding and transfusion requirements during orthotopic liver transplantation (OLT) and postoperatively, but hyperfibrinolysis appears to be the most important factor.
P Llamas, R Cabrera, J Gomez-Arnau, MN Fernandez   +3 more
doaj  

SARS-COV-2 causes significant abnormalities in the fibrinolysis system of patients: correlation between viral mutations, variants and thrombosis

Frontiers in Cellular and Infection Microbiology
BackgroundCoronavirus disease (COVID-19) is reported as a complex disorder affecting multiple systems and coagulopathy that can cause mortality. In this study, we investigated the correlation of SARS-CoV-2 mutations found in blood samples with various ...
Esra’a Abudouleh, Tarek Owaidah, Tarek Owaidah, Fatimah Alhamlan, Fatimah Alhamlan, Arwa A. Al-Qahtani, Reem M. Aljowaie, Fatimah Al-Ghnnam, Marie Fe Bohol, Ahmed A. Al-Qahtani, Ahmed A. Al-Qahtani   +10 more
doaj   +1 more source

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men [PDF]

, 2010
Hypofibrinolysis as measured with overall clot lysis assays is associated with risk of arterial thrombosis. Individual components of the fibrinolytic system, however, have not been studied extensively in relation to arterial disease, or results of ...
Doggen, Catharina Jacoba Maria; id_orcid, Lisman, T., Doggen, C.J.M., Rosendaal, F.R., de Groot, Philip G., Rosendaal, Frits R., Doggen, Carine J. M., Lisman, Ton; id_orcid, Meltzer, M.E., Lisman, Ton, Groot, P.G. de, Meltzer, Mirjam E.   +11 more
core   +1 more source

Hämostaseologische Veränderungen bei ,,idiopathischen" venösen Thrombosen im Kindes- und Jugendalter

, 1991
The prevalence of inherited thrombotic syndroms in the general population appears to be higher than that of inherited bleeding disorders. The most important candidates for screening are patients with unexplained venous thromboembolism at ages of less ...
Ehrenforth, S, Güngör, Tayfun; https://orcid.org/, Nowak-Göttl, Ulrike, Hach-Wunderle, Viola, Breddin, H K, Freund, Heike, Kreuz, W D, Kornhuber, B   +7 more
core   +1 more source

Correlation plots of hepatic candidate gene expression levels and plasma concentrations of the corresponding gene product.

, 2022
(A) Insulin-like growth factor-binding protein 1 (IGFBP-1). (B) Methionine adenosyltransferase 1A (MAT1A) and enzyme catalytic product (S-adenosylmethionine (SAM)). (C) Lipoprotein A (LPA). (D) Serpin family F member 2 (SERPINF2) and gene product alpha-2
Mathias B. Møllerhøj (13982927), Flemming P. Hjørne (13982936), Merete J. Kønig (13982933), Frederik Helgstrand (13378610), Urd L. Kielgast (12159792), Kristoffer T. G. Rigbolt (9091055), Henrik H. Hansen (143864), Martin R. Madsen (13982930), Jacob Jelsing (420565), Christoffer A. Hagemann (13982924), Anders Toxværd (13982939), Tina Vilsbøll (453259), Helene Ægidius (13982945), Filip K. Knop (8921179), Christian Legart (11986326), Jill L. Langhoff (13982942), Lise L. Gluud (3344306)   +16 more
core   +1 more source

a2-Antiplasmin Enschede: Dysfunctional alpha 2-antiplasmin molecule associated with an autosomal recessive hemorrhagic disorder

, 1987
??2-Antiplasmin (??2-AP) is a major fibrinolysis inhibitor, whose complete, congenital absence has been found to be associated with a distinct hemorrhagic diathesis.
Groeneveld, E., Berkel, W. van, Sixma, J.J., Dooijewaard, G., Kluft, C., Rijken, D.C., Wijngaards, G., Nieuwenhuis, H.K.   +7 more
core  

Demonstration of two forms of A2-antiplasmin in plasma by modified crossed immunoelectrophoresis

, 1981
A procedure to demonstrate two forms of ??2-antiplasmin in plasma, a plasminogen-binding and a non-plasminogen-binding one, is described. The procedure involves crossed immunoelectrophoresis using antiserum against ??2-antiplasmin, with, in the first ...
Kluft, C., Los, N.
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