Results 51 to 60 of about 18,078,412 (185)

Factor XIII Supplementation in Postpartum Hemorrhage: From Biological Rationale to Clinical Implementation

American Journal of Hematology, Volume 101, Issue 4, Page 794-806, April 2026.
ABSTRACT Postpartum hemorrhage (PPH) remains the leading cause of preventable maternal mortality despite standard interventions. Recent fibrinogen trials failed to improve outcomes, prompting interest in coagulation factor XIII (FXIII). FXIII functions as “molecular cement,” cross‐linking fibrin and stabilizing clots.
Jeremy W. Jacobs, Elizabeth A. Abels, Brian D. Adkins, Garrett S. Booth, Victoria Costa, Sheharyar Raza, Michelle Simon, Jennifer S. Woo, Allison P. Wheeler   +8 more
wiley   +1 more source

ADAM10‐Mediated Proteolytic Remodelling of Signalling and Adhesion Proteins on Brain Cell‐Derived Small Extracellular Vesicles

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Proteases are common components of extracellular vesicles (EVs), yet the extent and functional relevance of ongoing proteolytic activity on EV surfaces remain largely unexplored. Such activity could significantly influence EV function and identity, with likely implications for EV‐mediated signalling, recipient cell targeting, cargo delivery ...
Christopher C. Reimann, Hermann C. Altmeppen, Tomas Koudelka, Michaela Schweizer, Andreas Tholey, Behnam Mohammadi, Julia Bär, Lesley Cheng, Markus Glatzel, Marina Mikhaylova, Andrew F. Hill   +10 more
wiley   +1 more source

Inhibition of clot-bound alpha 2-antiplasmin enhances in vivo thrombolysis.

, 1990
Recent experiments in vitro have shown that inhibition of human alpha 2-antiplasmin by a monoclonal antibody (MAb RWR) markedly enhances clot lysis by plasminogen activators. To extend these studies in vivo, we tested whether inhibition of clot or fibrin-
G R Matsueda, E Haber, G L Reed
core   +1 more source

Alpha-1 antitrypsin deficiency gut microbiome

, 2020
This dataset contains 16S rRNA Illumina MiSeq sequenced samples used in our gut microbiome study in individuals with alpha-1 antitrypsin deficiency (AATD) and controls (non-AATD)
Kirst, ME (University of Florida)
core   +1 more source

Adipose Tissue‐Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance

Obesity, Volume 34, Issue 4, Page 896-907, April 2026.
ABSTRACT Objective Glucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT‐derived small extracellular vesicles (sEVAT) change in response to glucose availability and differ by GT status.
Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang‐Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep   +10 more
wiley   +1 more source

Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels

Communications Biology
Adiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated.
Andri Iona, Pang Yao, Alfred Pozarickij, Christiana Kartsonaki, Saredo Said, Neil Wright, Kuang Lin, Iona Millwood, Hannah Fry, Mohsen Mazidi, Baihan Wang, Yiping Chen, Huaidong Du, Ling Yang, Daniel Avery, Dan Schmidt, Dianjianyi Sun, Pei Pei, Jun Lv, Canqing Yu, Michael Hill, Junshi Chen, Fiona Bragg, Derrick Bennett, Robin Walters, Liming Li, Robert Clarke, Zhengming Chen, China Kadoorie Biobank Collaborative Group   +28 more
doaj   +1 more source

Plasma fibrin clots of pulmonary embolism patients present increased amounts of factor XIII and alpha2-antiplasmin at 3 months' anticoagulation since the acute phase

, 2020
Fibrin cross-linking by coagulation factor (F)XIII leads to clot stabilization. Reduced plasma FXIII levels have been reported in acute pulmonary embolism (PE) patients.
Bryk, Agata, Zeitl, K., Wisniewski, J., Sarkady, F., Bryk, A., Undas, A., Zettl, K., Wisniewski, Jacek, Natorska, J., Bagoly, Z., Katona, E., Katona, Eva, Bagoly, Zsuzsa, Barath, Barbara, Zabczyk, M., Natorska, Joanna, Ząbczyk, Michał, Undas, Anetta, Barath, B.   +18 more
core   +1 more source

Experimental infection of horses with African horse sickness virus results in overt disseminated intravascular coagulation

Equine Veterinary Journal, Volume 58, Issue 2, Page 619-629, March 2026.
Abstract Background African horse sickness (AHS), caused by the vector‐borne African horse sickness virus (AHSV), is endemic to sub‐Saharan Africa and infection results in high mortality in naïve equine populations. Clinical signs include submucosal petechiae and prolonged bleeding post venepuncture indicative of hypocoagulation.
Eva Christina Schliewert, Emma H. Hooijberg, Amelia Goddard   +2 more
wiley   +1 more source

Impaired Fibrinolysis in the Pathogenesis of Dengue Hemorrhagic Fever [PDF]

, 2002
The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever.
Eric C.M. van Gorp, ten Cate, H, Brandjes, DPM, Wil M.V. Dolmans, van der Meer, Jos W. M., Mairuhu, Albert T. A., Cate Ht, Hugo ten, Mairuhu, A.T., Brandjes, D.P., Cate, H.H., Setiati, T.E., Dolmans, W.M.V., Jos W.M. van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Mairuhu, ATA, Cate, H. ten, C. Erik Hack, Suharti, C., Catharina Suharti, Gorp, E. van, Brandjes, D.P.M., Albert T.A. Mairuhu, Dolmans, Wil M. V., Meer, J.W.M. van der, Setiati, Tatty E., Mairuhu, A.T.A., Tatty E. Setiati, Suharti, Catharina, Dees P.M. Brandjes, van Gorp, Eric C. M., Gorp, E.C.M. van, Brandjes, Dees P. M.   +33 more
core   +1 more source

Interventions to Prevent Postinflammatory Hyperpigmentation After Laser and Energy‐Based Device Treatments: A Systematic Review and Network Meta‐Analysis

Lasers in Surgery and Medicine, Volume 58, Issue 3, Page 157-168, March 2026.
ABSTRACT Background Postinflammatory hyperpigmentation (PIH) is the most common adverse effect following laser treatments, yet the relative efficacy of proposed prophylactic measures remains uncertain. Objectives To compare the effectiveness of available interventions for preventing laser‐induced PIH in randomized controlled trials (RCTs).
Supisara Wongdama, Sasitorn Yenyuwadee, Jayne Bernadeth Li, Surasak Saokaew, Sukrit Kanchanasurakit, Woraphong Manuskiatti   +5 more
wiley   +1 more source