Results 31 to 40 of about 18,078,412 (185)

Amino-Terminal Fusion of Epidermal Growth Factor 4,5,6 Domains of Human Thrombomodulin on Streptokinase Confers Anti-Reocclusion Characteristics along with Plasmin-Mediated Clot Specificity.

PLoS ONE, 2016
Streptokinase (SK) is a potent clot dissolver but lacks fibrin clot specificity as it activates human plasminogen (HPG) into human plasmin (HPN) throughout the system leading to increased risk of bleeding.
Neeraj Maheshwari, Satish Kantipudi, Anand Maheshwari, Kashika Arora, Vandana, Neha Kwatra, Girish Sahni   +6 more
doaj   +1 more source

The plasmin-antiplasmin system: structural and functional aspects [PDF]

, 2010
The plasmin-antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and (2)-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments.
Johann Schaller, Gerber, Simon S, Schaller, Johann, Simon S. Gerber   +3 more
core   +1 more source

Genetically Disparate Fayoumi Chicken Lines Show Different Response to Avian Necrotic Enteritis

The Journal of Poultry Science, 2015
Necrotic enteritis (NE) has reemerged as a significant problem as a result of growing restrictions of antibiotics in agricultural animal production and increasing concerns over antibiotic resistance in human pathogens.
Duk K. Kim, Hyun S. Lillehoj, Seung I. Jang, Sung H. Lee, Yeong H. Hong, Susan J. Lamont   +5 more
doaj   +1 more source

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]

, 2002
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Dolmans, Wil M.V., van der Meer, Jos W. M., Wil Dolmans, Setiati, T.E., Dolmans, W.M.V., C. Hack, Jos van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Djokomoeljanto, R.J., Cate, H. ten, Djokomoeljanto, Robert J., Cate, Hugo ten, Suharti, C., Catharina Suharti, Djokomoeljanto, Robert J., Gorp, E. van, Meer, J.W.M. van der, Dolmans, Wil M. V., Setiati, Tatty E., Meer, Jos W.M. van der, Eric van Gorp, Napel, C.H.H. ten, Gorp , Eric C.M. van, ten, Cate Hugo, Suharti, Catharina, Setiati , Tatty E., Robert Djokomoeljanto, Gorp, E.C.M. van, van Gorp, Eric C. M., Tatty Setiati   +31 more
core   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

The reactive site of human alpha 2-antiplasmin.

Journal of Biological Chemistry, 1987
Human alpha 2-antiplasmin rapidly forms a stable, equimolar complex with either its target enzyme, plasmin, or with trypsin. Perturbation of the inhibitor-trypsin complex results in peptide bond cleavage at the reactive site of the inhibitor with the concomitant release of a small peptide fragment which apparently represents the carboxyl-terminal ...
B H, Shieh, J, Travis
openaire   +2 more sources

Traumatic bleeding and mortality in mice are intensified by iron deficiency anemia and can be rescued with tranexamic acid

Research and Practice in Thrombosis and Haemostasis
Background: Clinical evidence suggests that anemia exacerbates traumatic bleeding and worsens outcomes. Objectives: To study the influence of iron deficiency anemia on traumatic bleeding, coagulopathy, and mortality.
Bilgimol Chumappumkal Joseph, Tro Sekayan, Nicca Falah, Richard F.W. Barnes, Veronica Flood, Juan A. De Pablo-Moreno, Annette von Drygalski   +6 more
doaj   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Fibrinolytic and coagulative activities of Yersinia pestis

Frontiers in Cellular and Infection Microbiology, 2013
The outer membrane protease Pla belongs to the omptin protease family spread by horizontal gene transfer into Gram-negative bacteria that infect animals or plants. Pla has adapted to support the life style of the plague bacterium Yersinia pestis. Pla has
Timo K. Korhonen, Johanna eHaiko, Liisa eLaakkonen, Hanna M Järvinen, Hanna M Järvinen, Benita eWesterlund-Wikström   +5 more
doaj   +1 more source