Results 21 to 30 of about 18,078,412 (185)

Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi

Scientific Reports, 2021
Venous thromboembolism is a significant source of morbidity and mortality worldwide. Catheter-directed thrombolytics is the primary treatment used to relieve critical obstructions, though its efficacy varies based on the thrombus composition.
Samuel A. Hendley, Alexey Dimov, Aarushi Bhargava, Erin Snoddy, Daniel Mansour, Rana O. Afifi, Geoffrey D. Wool, Yuanyuan Zha, Steffen Sammet, Zheng Feng Lu, Osman Ahmed, Jonathan D. Paul, Kenneth B. Bader   +12 more
doaj   +1 more source

Acute and chronic blood serum proteome changes in patients with methanol poisoning

Scientific Reports, 2022
Twenty-four blood serum samples from patients with acute methanol poisoning (M) from the mass methanol poisoning outbreak in the Czech Republic in 2012 were compared with 46 patient samples taken four years after poisoning (S) (overlap of 10 people with ...
Pavel Cejnar, Tatiana Anatolievna Smirnova, Stepanka Kuckova, Ales Prochazka, Ivan Zak, Karel Harant, Sergey Zakharov   +6 more
doaj   +1 more source

α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis

, 2022
Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
En Shu, Yosuke Kanno
core   +1 more source

The kidney is a major site of alpha(2)-antiplasmin production. [PDF]

Journal of Clinical Investigation, 1996
The serpin alpha2-antiplasmin (alpha2-AP) is the major circulating inhibitor of plasmin; it plays a determining role in the regulation of intravascular fibrinolysis, In addition to blood plasma, plasmin formation occurs in various organs where it is thought to fulfill a spectrum of functions not restricted to clot lysis.
Menoud, P. A., Sappino, N., Boudal-Khoshbeen, M., Vassalli, Jean-Dominique, Sappino, Pascal   +4 more
openaire   +3 more sources

Dysregulation of Biomarkers of Hemostatic Activation and Inflammatory Processes are Associated with Adverse Outcomes in Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction The pathophysiology of pulmonary embolism (PE) represents complex, multifactorial processes involving blood cells, vascular endothelium, and the activation of inflammatory pathways.
Iman Darwish B.S., Jawed Fareed PhD, Yevgeniy Brailovsky D.O., Debra Hoppensteadt PhD, Brett Slajus M.P.H., Emily Bontekoe B.S., Frank De Stefano B.S., Trent Reed D.O., Amir Darki MSc., M.D.   +8 more
doaj   +1 more source

Hyperbaric Oxygen Inhibits Reperfusion-Induced Neutrophil Polarization and Adhesion Via Plasmin-Mediated VEGF Release

Plastic and Reconstructive Surgery, Global Open, 2017
Background:. Ischemia-reperfusion (IR) injury is seen in many settings such as free flap salvage and limb replantation/revascularization. The consequences—partial/total flap loss, functional muscle loss, or amputation—can be devastating. Of the treatment
Ashish Francis, MD, Shawna R. Kleban, MD, Linda L. Stephenson, BS, Patrick S. Murphy, MD, Peter R. Letourneau, MD, Xin-Hua Fang, MT, Wei Z. Wang, MD, Richard C. Baynosa, MD   +7 more
doaj   +1 more source

Identification by whole genome sequencing of genes associated with delayed postoperative hemorrhage in Scottish deerhounds

Journal of Veterinary Internal Medicine, 2023
Background Delayed postoperative hemorrhage (DEPOH) is an important health concern for Scottish deerhounds. Hypothesis/Objectives Identify genes associated with DEPOH in Scottish deerhounds.
Michael H. Court, Jennifer N. Kiser, Holly L. Neibergs, Zhaohui Zhu, John E. Dillberger   +4 more
doaj   +1 more source

Fibrinolytic Status and Risk of Death After Acute Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis, 2023
Background Acute pulmonary embolism (PE) is a heterogeneous disease process with variable presentation and outcomes. The endogenous fibrinolytic system is a complex framework of regulatory pathways that maintains homeostasis by dissolving overabundant ...
Yevgeniy Brailovsky DO, MSc, Vladimir Lakhter DO, Joshua Newman MD, Sorcha Allen MBBCh, Ahmed Elkaryoni MD, Parth Desai MD, Dalila Masic PharmD, Carlos F. Bechara MD, Emily Bontekoe BS, Debra Hoppensteadt PhD, John J. Lopez MD, Fakiha Siddiqui BDS, Omer Iqbal PhD, Jawed Fareed PhD, Amir Darki, MD, MSc   +14 more
doaj   +1 more source

Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report [PDF]

, 2011
Background. Alpha II antiplasmin is a protein involved in the inhibition of fibrinolysis. A deficiency in this protein leads to increased hemorrhage. It is inherited in an autosomal recessive fashion. Case.
Brenda Dawley
core   +1 more source

X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin (2R9Y)

, 2016
The serpin alpha(2)-antiplasmin (SERPINF2) is the principal inhibitor of plasmin and inhibits fibrinolysis. Accordingly, alpha(2)-antiplasmin deficiency in humans results in uncontrolled fibrinolysis and a bleeding disorder.
Ruby Law (2569576), James Whisstock (2569573)   +1 more
core   +1 more source